Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

‘Who is zooming who’? A study of young PE-students in their figurations     

Stine Frydendal Nielsen  Lone Friis Thing 《Sport, Education and Society》2019,24(5):480-490

The article presents an analysis of 93 essays written in an upper secondary school context. The essays were collected in relation to a larger research project, which went on for 5 years in a Danish upper secondary school (2010–2015). The material represents both genders and the students are 15–17 years old. We deploy a theoretical framework taken from Norbert Elias’ notion on established-outsider relations [Elias, N., &; Scotson, J. L. (1994 [1965]). The established and the outsiders. London: SAGE] as well as his use of personal pronouns [Elias, N. (1978). What is sociology? London: Hutchinson, Elias, N. (2001). The society of individuals. New York: The Continuum International Publishing Group] in illustrating how people negotiate, position and navigate within figurational contexts [Elias, N. (1994 [1939]). The civilizing proces. Oxford: Blackwell.]. We do this in an effort to interpret how young people negotiate ‘we-I-relations’ when it comes to their sporting identity. Elias’ processual framework provides a tool for a much needed analysis of how young people continually orientate and develop their sense of selves. The web of human interdependencies and processes of change are key words when it comes to understanding the social practices and doings of the students’ constructions of self-steering. What social scientists may see as laziness and drop-outs of sports [Seippel, Ø. (2016). Prek, vekker og kjedelig? Trening og mening blant ungdom: 1985–2013. In Ø. Seippel, M. K. Sisjord, &; Å Strandbu (Eds.), Ungdom og Idrett. Oslo: Cappelen Damm Akademisk] can in the essays of students be analysed as a struggle for group connectedness and social inclusion in the classroom. The results of our research show that identity is a multiple concept and an ongoing process of emotional work [Elias, N. (1987). On human beings and their emotions: A process-sociological essay. Theory Culture Society, 4, 339–361], but also a power balance of playing and presenting what is imagined as the right performance as not being shamed as outcasts.  相似文献   

人力资本和社会资本对中国退役运动员收入影响比较     

张晓丽  阎晋虎 《上海体育学院学报》2020,(4):31-40

从人力资本和社会资本的视角出发,以316名中国退役运动员为研究对象,探讨这2种资本对退役运动员收入的影响,结果显示:①中国退役运动员的收入差异较大,平均收入状况不容乐观;②在人力资本的各观测变量中,运动等级、受教育程度、身体健康状况和职业技能培训依次对退役运动员收入产生影响;③在社会资本各观测变量中,弱关系和网络异质性对退役运动员收入影响显著;④人力资本有助于退役运动员进入中等收入群体,社会资本有助于其进入高收入群体;⑤人力资本和社会资本对退役运动员的收入提升作用显著,且人力资本作用高于社会资本。基于此,从政府和个体层面提出提升退役运动员人力资本和社会资本的建议。  相似文献   

被子植物精细胞分离和特性研究进展     

朱维红  张妍  崔彬彬 《保定学院学报》2020,(3):114-121

精细胞分离是研究雄性生殖发育的前提之一,近半个世纪以来,人们运用不断更新的生物实验技术,对被子植物精细胞开展了分离及细胞分子特征的研究。分析被子植物精细胞分离方法,总结精细胞二型性与倾向性、细胞融合方面的研究成果,并对其研究意义和前景进行讨论。  相似文献   

人性假设与人力资源管理   总被引：3，自引：0，他引：3  

石修俊  何富英 《玉溪师范学院学报》2003,19(4):8-11

人力资源管理的基础是人性假设 ,人性假设对人力资源管理具有导向作用。对人的认识不同 ,也就是人性假设不同 ,会有不同的选人用人政策 ,会有不同的人力资源管理方式。  相似文献   

职业体育俱乐部运动员人力资源价值计量研究     

虞力宏  陈坚坚 《中国体育科技》2005,41(4):67-68

采用文献资料调研和专家咨询法,根据微观经济学理论,运用人力资源会计中关于人力资源价值计量的货币性和非货币性方法,从成本与新增价值角度出发,对职业体育俱乐部的运动员人力资源价值计量模式进行研究。研究结果构建了运动员人力资源当期群体、当期个体、绩效、分配、未来群体、未来个体等6种价值计量模式,为职业体育俱乐部的人力资源管理提供依据。  相似文献   

普通高校运动员人力资本激励方式研究     

彭青军  朱凌玲 《河北体育学院学报》2006,20(4):42-44

依据人力资本理论,在对高校运动员人力资本特征进行分析的基础上,提出高校运动员人力资本激励应以鼓励为主;从运动员个体和群体层次提出多种相应的激励方式,并对其运用进行探讨。  相似文献   

法国人权保障机制的特色及其对中国的意义     

徐海珍  王丽红  徐晓静 《唐山学院学报》2005,18(4):61-63

我国现阶段在人权保障机制方面还存在很多漏洞,文章试从对法国宪法委员会制度的分析,概括法国人权保障机制的特色,并寻求其对中国在保障人权方面的借鉴意义。  相似文献   

人体体成份检测方法   总被引：4，自引：0，他引：4  

侯少华  侯曼 《体育科研》2004,25(6):35-39

通过文献法对国内外现有的人体体成份检测方法发展状况进行概述,显示:人们对人体组成成份的研究随着近年来检测仪器和设备的迅速发展而进一步深入,测量结果也越来越精确。  相似文献   

浅谈农村中小学体育人力资源的开发与利用   总被引：4，自引：0，他引：4  

陈巧弟  闫杰 《山西师大体育学院学报》2004,19(1):106-107

在经济、文化相对落后而又占有多数学生的农村中小学，开发和利用人力资源的优势，是实现农村中小学体育教育的一条重要途径。努力开发和利用农村中小学人力资源搞好农村中小学体育工作，是社会各界和广大教育者的责任。  相似文献