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1.
Relationship between hyperuricemia and metabolic syndrome 总被引：6，自引：0，他引：6
Chen LY Zhu WH Chen ZW Dai HL Ren JJ Chen JH Chen LQ Fang LZ 《Journal of Zhejiang University. Science. B》2007,8(8):593-598
Objective: To investigate the relationship between metabolic syndrome and hyperuricemia. Methods: A total of 2 374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our study. Hyperuricemia is defined as ≥7 mg/dl (in men) or ≥6.0 mg/dl (in women). Metabolic syndrome was defined using AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria. Results: (1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%). (2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased risk of metabolic syndrome as compared with those without hyperuricemia odds ratio (OR)=1.634, P=0.000. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia. Conclusion: Hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic syndrome. 相似文献
2.
目的 :评价甘油三酯 (TG)试剂盒抗还原性干扰的能力。方法 :用A、B、C三家公司试剂盒在RA -XT生化分析仪上测定含不同浓度胆红素、维生素C的混和血清的TG ,测定值除以各组对照血清测定值。结果 :A公司的TG试剂盒对 4 6 2 μmol/L以下的胆红素、0 .8g/L以下的维生素C具有良好的抗干扰能力 ,“得率”均大于 91%。其他公司的试剂盒“得率”呈不同程度降低 ,部分实验条件下竟为零。结论 :改善试剂盒的抗干扰能力十分重要。 相似文献
3.
P. Chandran N. K. Kuchhal P. Garg C. S. Pundir 《Indian journal of clinical biochemistry : IJCB》2007,22(2):145-150
Chemical composition of gall stones is essential for aetiopathogensis of gallstone disease. We have reported quantitative
chemical analysis of total cholesterol bilirubin, calcium, iron and inorganic phosphate in 120 gallstones from haryana. To
extend this chemical analysis of gall stones by studying more cases and by analyzing more chemical constituents. A quantitative
chemical analysis of total cholesterol, total bilirubin, fatty acids, triglycerides, phospholipids, bile acids, soluble proteins,
sodium potassium, magnesium, copper, oxalate and chlorides of biliary calculi (52 cholesterol, 76 mixed and 72 pigment) retrieved
from surgical operation of 200 patients from Haryana state was carried out. Total cholesterol as the major component and total
bilirubin, phospholipids, triglycerides, bile acids, fatty acids (esterified), soluble protein, calcium, magnesium, iron,
copper, sodium, potassium, inorganic phosphate, oxalate and chloride as minor components were found in all types of calculi.
The cholesterol stones had higher content of total cholesterol, phospholipids, fatty acids (esterified), inorganic phosphate
and copper compared to mixed and pigment stones. The mixed stones had higher content of iron and triglycerides than to cholesterol
and pigment stones. The pigment stones were richer in total bilirubin, bile acids, calcium, oxalate, magnesium, sodium, potassium,
chloride and soluble protein compared to cholesterol and mixed stones. Although total cholesterol was a major component of
cholesterol, mixed and pigment gall stone in Haryana, the content of most of the other lipids, cations and anions was different
in different gall stones indicating their different mechanism of formation. 相似文献
4.
Suchanda Sahu MBBS MD Rajinder Chawla Bharti Uppal 《Indian journal of clinical biochemistry : IJCB》2005,20(2):54-61
Current recommendations of the Adult Treatment Panel and Adolescents Treatment Panel of National Cholesterol Education Program
make the low-density lipoprotein cholesterol (LDL-C) levels in serum the basis of classification and management of hypercholesterolemia.
A number of direct homogenous assays based on surfactant/solubility principles have evolved in the recent past. This has made
LDL-C estimation less cumbersome than the earlier used methods. Here we compared one of the direct homogenous assays with
the widely used Friedewald’s method of estimation of LDL-C to see the differences and correlation. We used direct homogenous
assay kit to estimate serum LDL-C and high-density lipoprotein cholesterol (HDL-C). Serum Triglyceride (TG) and Total Cholesterol
(TC) was estimated and using Friedewald’s formula LDL-C was calculated. The LDL-C level obtained by both methods in 893 fasting
serum samples were compared. The statistical methods used were paired t-test and Pearson’s correlation.
There was significant difference in the mean LDL-C levels obtained by the two methods at the TG levels <200 mg/dl (p<0.02)
and TC levels >150 mg% (p<0.001). The correlation coefficient (r) between Friedewald’s and direct assay estimation was 0.88.
Friedewald’s method classified 23.5 % of patients as high cardiac risk whereas there were 17.58% by direct assay.
Both had good correlation even though the serum triglyceride and total cholesterol levels affect the difference in LDL-C estimated
by both methods. Taking into account the cost and performance, Friedewald’s method is as good or even better for classifying
and managing patients. 相似文献
5.
王娟 《河南科技学院学报》2006,34(3):91-93
血脂代谢异常是造成多种疾病发生的重要危险因素之一。大量的研究证实体育锻炼可以改善血脂状况，长期规律的体育锻炼均可有效的改善不良的脂质结构，增进人们的健康。 相似文献
6.
Sevil Kurban Idris Mehmetoglu Gulsum Yilmaz 《Indian journal of clinical biochemistry : IJCB》2007,22(2):44-47
The effects of sunflower oil, olive oil, margarine, soybean oil and butter on cholesterol and triglyceride levels were investigated
in the brain of rats. Rats were fed with a diet containing 15% of the oils for a period of 8 weeks. The rats were then decapitated,
brain samples were removed, homogenized and cholesterol and TG levels were measured. Brain cholesterol and Triglycerides levels
of all animals receiving different oils were significantly higher according to the contol except TG level of animals receiving
margarine. Brain cholesterol levels of the vegetable oils were statistically higher than those receiving saturated oil. Thus,
cholesterol level of the rats fed with olive oil group was significantly higher than that of the other groups but those receiving
sunflower oil group and Triglycerides level of the animals receiving olive oil was significantly higher than that of the other
groups except animal supplemented with soybean oil. Thus, it is concluded that brain lipid levels of rats are differently
effected by various oils and mechanism of which needs to be investigated. 相似文献
7.
缺血性脑血管病与血脂、脂蛋白水平相关性研究 总被引：1，自引：0，他引：1
目的：观察缺血性脑血管病（ICVD）患者血脂、脂蛋白的变化。方法：对113例缺血性脑血管病[包括脑梗塞（CI）急性期25例，恢复期30例，短暂性脑缺血发作（TIA）58例]和正常对照组77例进行血脂、脂蛋白测定。结果：脑梗塞组和TIA组甘油三酯（TG）、总胆固醇（TC）、载脂蛋白B100（ApoB100）、脂蛋白（a）（Lp（a））、氧化型低密度脂蛋白（OX—LDL）水平均显著高于对照组。结论：ICVD患者存在全面血脂、脂蛋白代谢紊乱。本结果对进一步了解ICVD的发病机理和治疗提供了依据，对于观察病情演变、判断预后均有重要意义。 相似文献
8.
Pushpa Durgawale Sangita Patil P. S. Shukla Ajit Sontakke Satish Kakade Sunil Yadav 《Indian journal of clinical biochemistry : IJCB》2009,24(1):30-35
Fasting samples of 914 subjects from healthy population were analyzed for total cholesterol, triglyceride and three major
fractions of lipoproteins i.e. high-density lipoprotein cholesterol, low lipoprotein cholesterol and very low-density lipoprotein
cholesterol. The values obtained were (in mg/dl) 165.7±30.2,88.36±31.2, 44.86±10.68, 101.66±29.8 and 18.11±7.35 respectively.
When these subjects were grouped according to the age and sex, no appropriate differences were observed between most of the
groups. Triglycerides were found to be low and HDL cholesterol was high in female when compared with male of similar age.
Beyond age 40 years cholesterol level and low density lipoprotein cholesterol was found to be gradually increased in case
of women. Minor difference was observed with dietary pattern. Present study suggests that clinical evaluation of patient should
be made on the basis of these reference values for Western Maharashtra population. 相似文献
9.
Devendra K. Rai Prashant Kumar Rai Aradhna Gupta Geeta Watal Bechan Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(2):198-201
Wistar rats of 6–8 weeks in age weighing between 120–150 g were exposed to the fixed doses of each of the carbamate pesticides
such as cartap (50% LD50) and carbofuran (50% LD50) as well as a combination of these two with 25% LD50 of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-density lipoprotein,
total cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein. Treatment with individual doses
of carbofuran (50% LD50) and cartap (50 % LD50) caused significant alterations in the levels of serum lipid parameters. The pesticides treatment resulted in marked decrease
in the level of serum high-density lipoprotein where as that of other lipids got significantly elevated. Further, the rats
exhibited relatively higher impact of pesticides when treated with the compounds in combination (25 % LD50 of each). The results indicated that these compounds when used together may exert enhanced effect on the levels of serum
lipids in rat. 相似文献
10.
大豆黄酮对固始鸡血液及肌肉组织中胆固醇和甘油三酯含量的影响 总被引：1，自引：0，他引：1
选择1日龄健康固始鸡120只,按体重相近的原则,随机分为4组,即对照组、试验Ⅰ、Ⅱ和Ⅲ组(n=30).对照组饲喂基础日粮,试验组在基础日粮中分别添加10、20和30mg/kg的大豆黄酮,试验期为42d.在第2、4、6周龄每组随机抽取10只鸡称重,并屠宰.测定鸡血清、胸肌、腿肌中胆固醇和甘油三酯的含量,以探讨大豆黄酮对固始鸡血清及组织中胆固醇和甘油三酯含量的影响.结果表明,基础日粮中添加10-30mg/kg的大豆黄酮,可显著或极显著降低血清胆固醇水平(P＜0.05或P＜0.01);添加20 mg/kg的大豆黄酮,4、6周龄时可显著降低血清甘油三酯水平(P＜0.05).添加大豆黄酮可降低固始鸡胸肌胆固醇和甘油三酯,但对腿肌胆固醇和甘油三酯水平影响不显著. 相似文献