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1.
目的：进一步探讨脊髓型颈椎病与发育性颈椎管狭窄的关系。方法：应用比值法对70例正常人和110例脊髓型颈椎病患者的X线侧位片进行统计学测量与比较，研究范围从C3～C7。结果：C3～C7正常组与颈椎病组的椎管中矢径比值有显著性差异。结论：发育性颈椎管狭窄是脊髓型颈椎病的重要发病因素。 相似文献
2.
目的：探讨耐药基因p-糖蛋白（p-gp）、谷胱甘肽-S-转移酶（GST-Ⅱ）、拓扑异构酶Ⅱ（TOpoⅡ）、胸苷酸合成酶（TS）在宫颈癌中的表达及临床意义。方法：应用免疫组织化学方法检测65例宫颈癌中p-gp、TOpoⅡ、GST-π、TS的表达，并分析其与临床预后之间的关系。结果：p-gp的表达与肿瘤分化程度、淋巴结转移有关（P〈0．05），与UICC分期、局部复发无关（P〉0．05）；TOpoⅡ的表达与淋巴结转移、局部复发有关（P〈0．05），与肿瘤分化程度、UICC分期无关（P〉0．05）；GST-π的表达与各个指标之间均存在相关（P〈0．05）；TS与淋巴结转移、UICC分期有关（P〈0．05），与局部复发、肿瘤分化无关（P〉0．05）。经多因素COX比例风险模型分析显示：局部复发、淋巴结转移及TOPOⅡ、GST-π的表达与宫颈癌患者术后生存率有关（P〈0．05）。结论：宫颈癌中p-gp、TOpoⅡ、GST-π、TS的联合检测对判断宫颈癌的预后十分必要；局部复发、淋巴结转移及TOpoⅡ、GST-π的表达可作为宫颈癌患者独立的预后因素。 相似文献
3.
ncer. CT simulation may be a feasible technique for planning pelvic fields optimally and individually. 相似文献
4.
Nathan Walter Sheila T. Murphy Lauren B. Frank Lourdes Baezconde-Garbanati 《Communication Research Reports》2017,34(2):161-170
Limited attention has been given to the medium of story presentation in this process of narrative persuasion. The present study (N = 243) fills this gap by directly comparing narrative involvement across print and audiovisual versions of the same cervical cancer-related story. The mediation analysis revealed that exposure to an audiovisual narrative was associated with higher levels of cognitive and emotional involvement than exposure to the exact same narrative in its printed form. Yet the higher levels of transportation in the audiovisual condition came at a price of enhancing psychological reactance, eliminating the relative advantage of the film narrative. 相似文献
5.
M. Smita K. Naidu A. N. Suryakar Sanjay C. Swami R. V. Katkam K. M. Kumbar 《Indian journal of clinical biochemistry : IJCB》2007,22(2):140-144
Cervical cancer (CaCx) is a global public health problem as it is the second most common cancer leading to the death of women
worldwide. Many references revealed that the low levels of antioxidants induce the generation of free radicals leading to
DNA damage and further mutations. In the present study attempt have been made to evaluate the levels of serum Lipid peroxide,
Nitric Oxide (NO.) Erythrocytic—Superoxide Dismutase (RBC-SOD), Vitamin-C, serum Copper (Cu) and serum Zinc (Zn). 120 patients were divided
in 4 groups according to the increasing CaCx stages i.e. stage I, II, III & IV respectively. All the patients were around
the age group of 25–65 years. 30 healthy women between the same age group were treated as controls. Highly significant increased
values of MDA, NO. and Cu were observed (p<0.001) whereas the activity of RBC-SOD, levels of Vitamin-C and Zn were significantly decreased in
CaCx patients as compared with healthy controls (p<0.001). Cu/Zn ratio was found to be altered in CaCx patients. From our
findings it can be concluded that the oxidative stress is induced among CaCx patients, which inturn increases the risk of
CaCx. 相似文献
6.
目的：探索利用图像存储传输系统（PACS）多维测量颈椎椎弓根64排CT片指导术中置钉,提高置钉一次成功率的效果。方法：应用PACS结合64排CT片,由5名医师对2000例正常人颈椎椎弓根的冠状位、矢状位及轴位进行精确测量,得出国人椎弓根的长度、宽度、高度及向内侧倾斜、向头、尾侧倾斜角度的数据值,以指导术中选钉及置钉。颈椎椎弓根内固定术前参考上述内容,对拟固定颈椎椎弓根的283例患者进行多维精确测量,得出椎弓根的上述数据值,其中上颈椎疾患91例,下颈椎疾患192例。术中应用自行研制的颈椎椎弓根定位导向器,准确定位人钉点及角度,置钉1198枚。结果：257例患者获得8～73个月随访,平均随访时间18．16个月。上颈椎患者3例螺钉穿破寰椎左侧椎弓根外侧壁,未发现脊髓、椎动脉损伤,未行二次手术,未发现钉板断裂,CT片示螺钉与椎动脉及脊髓位置关系良好。下颈椎患者中,16例患者17枚椎弓根螺钉术后拍片位置不理想,行二次手术调整位置满意,一次成功率98．58％。该组患者采用JOA评分标准,优132例,良102例,可18例,差5例,优良率91．05％。结论：应用PACS结合64排CT片术前三维精确测量,指导术中置入颈椎椎弓根螺钉,明显提高植钉的一次成功率,是一种可行的方法。 相似文献
7.
颈椎病是指因颈椎间盘退行性变、颈椎肥厚增生以及颈部损伤等引起的疾病,是中、老年人的常见病、多发病之一,多见于40岁以上病人。随着人们工作性质和工作条件的改变,颈椎病的发病年龄已经提前到40岁以前,已成为骨科的常见病,需要手术治疗的病人也越来越多,颈椎病病人的护理已成为骨科病房的重要工作之一。 相似文献
8.
目的:探讨刺五加注射液对人宫颈癌细胞株Hela体外增殖的抑制作用。方法:采用MTT法测定了不同浓度的刺五加注射液对人宫颈癌细胞株Hela的体外抑制作用,倒置显微镜观察细胞形态变化。结果:刺五加注射液浓度越高对Hela细胞抑制作用越好,作用时间越长抑制效果越强,量效关系和时效关系良好;形态学观察到细胞凋亡。结论:刺五加注射液对人宫颈癌细胞株Hela的细胞增殖有较强的抑制作用。 相似文献
9.
Priyanka Srivastava Saumya Pandey Balraj Mittal Rama D. Mittal 《Indian journal of clinical biochemistry : IJCB》2013,28(1):13-18
Matrix metalloproteinase [MMP]-2 and tissue inhibitor of metalloproteinase [TIMP]-2 are emerging as pivotal players in inflammation and carcinogenesis. The present study aimed to evaluate the role of MMP-2 (−735C > T) [rs 2285053] and TIMP-2 (−418G > C) [rs 8179090] gene polymorphisms in cervical cancer susceptibility in Indian women. We recruited 200 cervical cancer patients from North India and 200 unrelated, age-matched, cancer-free healthy female controls of similar ethnicity. Genomic DNA extraction from peripheral blood samples, collected from the study subjects, was carried out using salting-out method. MMP-2 and TIMP-2 genotyping was performed using polymerase chain reaction-based restriction fragment length polymorphism. Our findings demonstrated no significant association between MMP-2 (−735C > T) and TIMP-2 (−418G > C) gene polymorphisms and the risk of developing cervical cancer in the study population. Further stratified analysis using a case-only study approach revealed that there was no effect of MMP-2/TIMP-2 polymorphisms on early and advanced stages of cervical cancer. Further MMP-2 and TIMP-2 polymorphisms did not modulate the risk in cervical cancer patients who smoked tobacco/cigarettes. Overall, the present study demonstrated a lack of association between MMP-2 and TIMP-2 gene polymorphisms and cervical cancer susceptibility in women of Northern India. 相似文献
10.
目前,人们研究肿瘤的热点已经从癌基因转到抑癌基因,在已发现的数个抑癌基因中,p53、Fas、p16、Fhit、nm23、BLCAP与宫颈癌的关系密切,也是宫颈癌研究的热点.p53和p16基因通过调控细胞周期来抑制细胞增殖;Fas通过与其配体FasL或其单克隆抗体结合后,诱导Fas所在细胞凋亡;Fhit通过诱导细胞凋亡、细胞周期阻滞发挥着抑制肿瘤细胞增殖的作用;nm23则是通过改变nm23基因的编码产物二磷酸核苷酸激酶(NDPK)从而引起NTP产生不足,参与浸润、转移过程;BLCAP是一个新近发现的宫颈癌相关抑癌基因,其功能及性质尚不大清楚. 相似文献