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心血管疾病(cardiovascular disease,CVD)是包括动脉粥样硬化、心力衰竭、心脏缺血后再灌注损伤和心肌梗死等血管和心脏的复杂病症。血管内皮细胞、平滑肌细胞和心肌细胞生理功能障碍是诱发CVD的关键因素。研究表明,运动能够对心脏和动脉的形态、功能起到积极的调控作用,可作为CVD非药物疗法的重要手段之一。运动可通过调控多种运动因子的表达水平,如肌肉分泌的Fstl1、Irisin和MSTN,脂肪分泌的Omentin、Apelin、CTRP3和CTRP9,肝脏分泌的FGF21、ANGPTL3和ANGPTL4等,进而调控血管内皮细胞、平滑肌细胞和心肌细胞的分化、增殖和凋亡,从而发挥其防治CVD作用。本文试图梳理肌肉、脂肪和肝脏分泌的运动因子与调控心脏和动脉功能之间的相关信号通路及其机制,为运动干预防治CVD提供新的思路。 相似文献
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目的：探讨不同运动方式与机械应力变化对内皮素的影响及其生物学机制。方法：采用文献综述法及归纳与梳理、分析与推理等研究方法对持续训练与间歇训练、耐力训练与力量训练、力竭训练与过度训练及低氧训练对血浆内皮素的影响作以综述，对切应力、压应力、一氧化氮和降钙素基因相关肽对内皮素的影响进行分析。结果与结论：不同的运动方式与机械应力变化对内皮素的影响存在着差异性，其机制是由于运动方式所介导的机械应力变化与化学因素刺激引起了内皮细胞内一系列生物学变化导致的。 相似文献
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为了了解运动训练中内皮素对心血管系统的作用.采用文献资料法论述了内皮素的主要生理作用,综述了国内外有关内皮素与运动训练关系的研究现状及该领域研究中存在的问题.研究表明:适宜强度的有氧耐力运动,可以改善内皮素的释放量进而有利于心血管系统在运动训练中的适应. 相似文献
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血管内皮细胞（VEC）及其分泌的生物活性物质在调节血管张力中起重要作用．它们与各种心血管疾病密切相关。现已认为有规律的运动对预防和治疗心血管疾病是有效的。运动引起的心血管保护机制中内皮细胞被认为是最重要的靶点。讨论了运动对VEC的形态，内分泌、黏附功能以及受体表征和凋亡的变化，了解运动对VEC的影响，有助于指导未来心血管疾病预防的研究。 相似文献
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NF-κB是一种具有基因转录多项调控作用的转录因子,广泛存在于各种细胞中.NF-κB的活化在心血管疾病的发生发展过程中起着重要的作用.大强度疲劳运动引起运动性心血管重塑,其与心血管疾病的病理生理过程具有相同的生物学机制.由此推测,运动引起运动性心血管重塑与NF-κB的活化关系密切. 相似文献
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Objective： Study blood vessel injury and gene expression indicating vascular endothelial cell apoptosis induced by mannitol with and without administration of anti-oxidative vitamins. Methods： Healthy rabbits were randomly divided into four groups. Mannitol was injected into the vein of the rabbit ear in each animal. Pre-treatment prior to mannitol injection was per- formed with normal saline （group B）, vitamin C （group C） and vitamin E （group D）. Blood vessel injury was assessed under electron and light microscopy. In a second experiment, cell culture specimen of human umbilical vein endothelial cells were treated with mannitol. Pre-treatment was done with normal saline （sample B）, vitamin C （sample C） and vitamin E （sample D）. Total RNA was extracted with the original single step procedure, followed by hybridisation and analysis of gene expression. Results： In the animal experiment, serious blood vessel injury was seen in group A and group B. Group D showed light injury only, and normal tissue without pathological changes was seen in group C. Of all 330 apoptosis-related genes analysed in human cell culture specimen, no significant difference was seen after pre-treatment with normal saline, compared with the gene chip without pre-treatment. On the gene chip pre-treated with vitamin C, 45 apoptosis genes were down-regulated and 34 anti-apoptosis genes were up-regulated. Pre-treatment with vitamin E resulted in the down-regulation of 3 apoptosis genes. Conclusion： Vitamin C can protect vascular endothelial cells from mannitol-induced injury. 相似文献
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Proliferation of endothelial cell on polytetrafluoroethylene vascular graft materials carried VEGF gene plasmid 总被引：1，自引：0，他引：1
Tao SF Chen L Zheng YX Xu Y Chen J Yu H 《Journal of Zhejiang University. Science. B》2006,7(6):421-428
Objective： To investigate whether vascular endothelial growth factor （VEGF） gene plasmid carried by polytetrafluoroethylene （PTFE） vascular graft materials could transfect endothelial cells （ECs） and promote their growth. Methods： PTFE vascular graft materials carried with pCDI-hVEGF121, pCDI or pEGFP were incubated in Tris-buffer solution and the values of optical density of 260 nm at different time were plotted, then the DNA controlled release curve was made. ECs derived from human umbilical vein were seeded on the pCDI-hVEGF121/pCDI/pEGFP-PTFE materials or tissue culture plates, ECs numbers were counted and VEGF protein concentrations at different time were measured by enzyme-linked immunoadsorbent assay method. Green fluorescent protein （GFP） expression in ECs on pEGFP-PTFE materials was examined with fluorescence mi- croscopy. Results： The controlled release curve showed that the gene released from PTFE materials was rapid within 8 h, then slowed down and that the gene released continuously even after 72 h. At 24, 72 and 120 h, ECs number and proliferation rate of pCDI-hVEGFI21-PTFE materials were higher than those ofpCDI or pEGFP-PTFE materials （P〈0.05）. VEGF protein concentration of pCDI-hVEGF121-PTFE materials was higher than that of pC DI or pEGFP-PTFE materials at 6, 24, 72 and 120 h （P〈0.01）. GFP expression in ECs on the pEGFP-PTFE materials could be detected by fluorescence microscopy. Conclusion： PTFE graft can be used as a carrier of VEGF gene plasmid, VEGF gene carried by PTFE can transfect ECs and promote ECs growth. 相似文献
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糖尿病是一种以高血糖为主要特征的非传染性慢性疾病,主要表现为持续性血糖升高、胰岛素抵抗、血脂代谢紊乱。由糖尿病造成的血管并发症是糖尿病患者致残、致死的主要原因。运动是糖尿病的有效预防与治疗手段,对糖尿病血管并发症有良好的控制和改善作用。总结糖尿病血管并发症原因及运动对其改善机制,进一步了解运动对促进糖尿病血管健康的重要作用与意义。 相似文献
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通过建立人脐静脉内皮细胞（HUVEC）体外培养，采用电镜、免疫组化等技术观察肿瘤坏死因子－a（TNF－a）对HUVEC的存活率、形态和凋亡相关蛋白的影响，从而探讨TNF－a致血管内皮细胞（VEC）损伤的分子机制以及临床意义。 相似文献