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1.
S. Kaushik S. S. Trivedi A. Jain J. Bhattacharjee 《Indian journal of clinical biochemistry : IJCB》2002,17(2):68-73
Colostrum, the mammary secretion during first 2–4 days of lactation, provides all the essential components of nutrition and
passive immunity required by the newborn. Pregnancy induced hypertension (PIH), glucose intolerance and anaemia are common
medical complications observed during pregnancy in Indian women and their effects were studied on the composition of colostrum
collected within 24 hours of delivery from lactating women included in the study. PIH during pregnancy significantly decreased
colostrum IgA and total proteins, but showed a significant increase in K+ levels, where as women with glucose intolerance showed a significant decrease in total lipids and lactose and an increase
in Na+ levels in colostrum compared to normal controls. The group with anaemia also showed a significant decrease in colostrum IgA
and total protein levels when compared with the control group. Awareness about the changes that occur in the composition of
colostrum during complicated pregnancies can be an important and useful tool for preventive and protective paediatrics. 相似文献
2.
目的:探讨乳腺肿瘤组织中热休克蛋白HSP70和DNA修复酶O6-甲基鸟嘌呤-DNA甲基转移酶(O6-methyguanine-DNA methytransferase,MGMT)的表达及临床意义。方法:采用免疫组织化学SABC法检测65例乳腺肿瘤组织中HSP70和MGMT的表达情况。结果:乳腺肿瘤中HSP70的阳性率为80.00%(52/65),MGMT的阳性率为60.00%(39/65),二者呈中度相关性(r=0.46)。其中,有淋巴结转移组的阳性率高于无转移组(P<0.05)。结论:HSP70和MGMT的表达率与淋巴结转移情况有关。检测HSP70与MGMT对乳腺肿瘤预后和化疗方案的选择有指导意义。 相似文献
3.
The salt-gradient operation mode used in ion-exchange simulated moving bed chromatography (SMBC) can improve the efficiency of protein separations. A detailed model that takes into account any kind of adsorption/ion-exchange equilibrium, salt gradient, size exclusion, mass transfer resistance, and port periodic switching mechanism, was developed to simulate the complex dynamics. The model predictions were verified by the experimental data on upward and downward gradients for protein separations reported in the literature. All design and operating parameters (number, configuration, length and diameter of columns, particle size, switching period, flow rates of feed, raffinate, desorbent and extract, protein concentrations in feed, different salt concentrations in desorbent and feed) can be chosen correctly by numerical simulation. This model can facilitate the design, operation, optimization, control and scale-up of salt-gradient ion-exchange SMBC for protein separations. 相似文献
4.
研究了槲皮素与蛋白质在pH=4.20条件下作用的共振光散射特征，并以此建立了测定微量蛋白质的新方法。考察了影响因素，确定了最佳反应条件。对牛血清白蛋白，测定的线性范围为0－5.0mg/L。检测限57.5μg/L。方法用于人血清试样中总蛋白的测定，结果与经典的考马斯亮兰法一致。 相似文献
5.
本文对梅花鹿体血和茸的外现特征进行了比较,并对两者的血清蛋白质、氨基酸及无机元素含量进行了测试比较,为鹿血产品的开发提供科学依据。并对鹿血酒中的氨基酸和微量元素进行了测定。 相似文献
6.
Asaolu Modupe Fisayo 《Indian journal of clinical biochemistry : IJCB》2007,22(2):93-95
The plasma concentrations of total protein, albumin, immunoglobulins IgG, IgA and IgM and urinary protein were assayed in
250 pregnant Nigerian women with malaria and compared with 250 healthy pregnant women which served as controls. The mean values
of plasma total proteins, albumin, IgG and IgA were significantly lowered (P<0.05) while a slight increase in IgM was observed
in the malaria patients. Urinary proteins value of 23.10±0.50 mg/dl was obtained for the pregnant women with malaria, this
was significantly higher (P<0.05) than that of the controls with the corresponding value of 15.32±0.09 mg/dl. This study has
therefore demonstrated elevations of the urinary and decrease in plasma proteins in gestational malaria. These findings suggest
that the protein profile should be considered in the diagnosis and treatment of malaria. 相似文献
7.
卢建刚 《浙江大学学报(A卷英文版)》2004,5(12):1613-1620
The salt-gradient operation mode used in ion-exchange simulated moving bed chromatography (SMBC) can improve the efficiency of protein separations. A detailed model that takes into account any kind of adsorption/ion-exchange equilibrium, salt gradient, size exclusion, mass transfer resistance, and port periodic switching mechanism, was developed to simulate the complex dynamics. The model predictions were verified by the experimental data on upward and downward gradients for protein separations reported in the literature. All design and operating parameters (number, configuration, length and diameter of columns, particle size, switching period, flow rates of feed, raffinate, desorbent and extract, protein concentrations in feed, different salt concentrations in desorbent and feed) can be chosen correctly by numerical simulation. This model can facilitate the design, operation, optimization, control and scale-up of salt-gradient ion-exchange SMBC for protein separations. 相似文献
8.
本文应用银染细胞核仁组成区(AgNORs)技术,对34例胃腺癌(GAC),96例不同病理类型胃炎进行 AgNORs 颗粒计数。结果显示:胃腺癌与各型胃炎均有显著性差异;胃粘膜癌前病变(本文指胃炎伴不典型增生(CGAH)。胃炎伴肠化(CGIM)慢性萎缩性胃炎(CAG))均与慢性浅表性胃炎(CSG)有显著性差异。故 AgNORs 在胃粘膜良恶性疾病的鉴别及癌前病变的诊断上具有一定意义。 相似文献
9.
Klaus H. Theopold 《Journal of The Franklin Institute》2005,342(6):586-591
The Franklin Institute, Philadelphia, Pennsylvania, awarded the 2004 Benjamin Franklin Medal in Chemistry to Harry B. Gray for his pioneering contributions in the field of electron transfer in metalloproteins. In a series of elegant and challenging experiments beginning in the late 70s, Gray and his coworkers have shown that the transfer of electrons in metalloproteins can proceed over long distances (~ 20 Å) and at fast rates. These experiments have involved the regiospecific functionalization of structurally characterized electron transfer proteins with ruthenium complexes, coupled with laser excitation and transient spectroscopy. Probing the effects of thermodynamic driving force, temperature, donor-acceptor distance and electronic coupling, Gray has shaped our detailed current understanding of the principles governing biological electron flow. The mechanism of electron transfer has been identified as electron tunneling mediated by the molecules separating donor and acceptor. Tunneling timetables have been established for various intervening media. Important biological processes like respiration and photosynthesis depend on facile electron transfer, and Gray's contribution serves as the fundamental basis for understanding these and many related reactions. 相似文献
10.
目的:探讨HSP27和HSP70 mRNA在大肠癌中表达的临床意义。方法:取大肠癌标本77例,采用免疫组织化学方法检测HSP27的表达状况,从中选取36例手术标本,采用核酸原位杂交技术(ISH)检测HSP70 mRNA的表达。结果:HSP27和HSP70 mRNA在大肠癌中的阳性率分别为40.3%和66.9%,HSP27和HSP70 mRNA均与大肠癌的分化程度相关,与发生部位、浸润深度及淋巴结转移无明显相关性。结论:检测HSP27和HSP70 mRNA可作为大肠癌患者预后的一个重要指标。 相似文献