耐力性运动防治血脂异常的机制   总被引：1，自引：0，他引：1  

张培珍  田野 《西安体育学院学报》2007,24(2):66-69

血脂异常是冠心病的首要危险因素,因此,如何通过安全有效的方式防治血脂异常,进而防治冠心病一直是学术界研究的热点。运动疗法作为防治血脂异常的安全有效的手段,正日益受到国内外专家学者的关注。  相似文献   

运动训练对血脂异常的防治     

张培珍  田野 《北京体育大学学报》2006,29(10):1353-1356,1369

血脂异常是冠心病的首要危险因素,因此,如何通过安全有效的方式防治血脂异常,进而防治冠心病一直是学术界研究的热点.运动疗法作为防治血脂异常的安全有效的手段,正日益受到国内外专家学者的关注.该文综述了运动训练对血脂异常的防治方面的研究进展.  相似文献   

ApoE基因多态性和运动与血脂异常的关系   总被引：1，自引：0，他引：1  

张慧敏 《德州学院学报》2008,24(2):64-68

载脂蛋白E有ApoE2、ApoE3和ApoE4三种主要的异构体,有ε2、ε3和ε4三种常见的等位基因,其基因编码可形成ApoE2/2、ApoE3/3、ApoE4／4三种纯合子表型和ApoE3／2、ApoE4/3、ApoE2／4三种杂合子表型．不同种族间ApoE等位基因的频率和基因型频率都不同．载脂蛋白E基因多态性是个体间血脂水平差异的常见遗传因素,与个体间血脂代谢和血脂异常的发生存在有一定的关联．此外,载脂蛋白E基因多态性可调节运动对血脂的影响作用,但其机制还有待于进一步的研究．  相似文献   

健身气功·五禽戏对血脂异常患者干预作用的研究   总被引：1，自引：0，他引：1  

李兆伟  周丽娟 《广州体育学院学报》2009,29(4)

实验观察了健身气功·五禽戏对血脂异常患者的干预作用.66例血脂异常患者随机分为两组,治疗组选用五禽戏的锻炼方式,对照组选用慢跑的锻炼方式,两个疗程结束后观察两组TC、TG、LDL-C、HDL-C四项指标的变化并比较调脂治疗的达标率.检测结果显示,两个疗程结束后治疗组患者的TC、TG、LDL-C、HDL-C四项指标和治疗前相比均有显著改善(P<0.01,P<0.05),并且对TC、TG、LDL-C的调节作用明显优于对照组(P<0.05);治疗组的调脂治疗达标率显著高于对照组(P<0.05).说明健身气功·五禽戏对血脂异常患者有显著的调脂作用,可有效降低心血管疾病的发病危险,建议在社区中大力推广.  相似文献   

Water-Based Aerobic Training Successfully Improves Lipid Profile of Dyslipidemic Women: A Randomized Controlled Trial     

Rochelle Rocha Costa  Carmen Pilla  Adriana Cristine Koch Buttelli  Michelle Flores Barreto  Priscila Azevedo Vieiro  Cristine Lima Alberton 《Research quarterly for exercise and sport》2018,89(2):173-182

Purpose: This study aimed to investigate the effects of water-based aerobic training on the lipid profile and lipoprotein lipase (LPL) levels in premenopausal women with dyslipidemia. Method: Forty women were randomly assigned to: aquatic training (WA; n = 20) or a control group (CG; n = 20). The WA group underwent 12 weeks of water-based interval aerobic training twice a week at intensities ranging from 9 to 15 on the Borg Scale of Perceived Exertion. Total cholesterol (TC), triglycerides (TG), high- (HDL) and low- (LDL) density lipoprotein, TC/HDL ratio, LPL levels, and peak oxygen consumption (VO₂peak) were evaluated before and after 12 weeks in both groups. Results: The WA group elicited decreases in TC (9%; effect size [ES] = 0.69; 95% CI [0.05, 1.33]), LDL (16%; ES = 0.78; 95% CI [0.13, 1.42]), and the TC/HDL ratio (17%; ES = 1.13; 95% CI [0.46, 1.79]), as well as increases in VO₂peak (10%; ES = 0.64; 95% CI [0.002, 1.27]) and HDL (10%; ES = 0.28; 95% CI [?0.35. 0.90]), without significant changes in TG (ES = 0.16; 95% CI [?0.46, 1.79]) and LPL (ES = 0.36; 95% CI [?0.27, 0.98]) levels. In the CG, no statistically significant changes in any of these variables were found (TC, ES = 0.19, 95% CI [?0.43, 0.82]; LDL, ES = 0.22, 95% CI [?0.40, 0.85]; HDL, ES = 0.05, 95% CI [?0.57, 0.67]; TG, ES = 0.09, 95% CI [?0.53, 0.71]; TC/HDL ratio, ES = 0.20, 95% CI [?0.42, 0.82]; LPL, ES = 0.02, 95% CI [?0.60, 0.64]; VO₂peak, ES = 0.20, 95% CI [?0.42, 0.82]). Conclusion: Water-based interval aerobic training positively affected the lipid profile in premenopausal dyslipidemic women.  相似文献   

不同剂量辛伐他汀治疗2型糖尿病血脂紊乱的临床观察     

王晓梅  于晓静 《大连大学学报》2007,28(3):78-80

[目的]:观察不同剂量的辛伐他汀对2型糖尿病的高血脂治疗疗效.[方法]:将104例根据临床症状、血糖及存在不同程度脂代谢紊乱患者随机分成辛伐他汀20 mg、40 mg及80 mg治疗组,于治疗24周复查血脂.[结果]:辛伐他汀常规剂量和强化治疗均能降低总胆固醇和低密度胆固醇作用,强化治疗效果更好.[结论]:辛伐他汀强化治疗剂量明显优于常用处方剂量.  相似文献   

Investigation of ABCA1 C69T polymorphism in patients with type 2 diabetes mellitus     

Ergen HA  Zeybek U  Gök O  Karaali ZE 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):114-120

Introduction:

Non insulin dependent diabetes mellitus is the most common type of diabetes. Genetic factors, lipid profiles, hypertension are potential risk factors for diabetes mellitus. Adenosine binding cassette transporter proteins 1 (ABCA1) plays a role in cholesterol metabolism, especially high density lipoprotein (HDL-cholesterol). There are multiple mechanisms by which HDL-cholesterol can be atheroprotective, it is clear that the relative activity of ABCA1 plays a major role. We aimed to investigate association of ABCA1 C69T gene polymorphism with lipid levels in Turkish type 2 diabetic patients.

Materials and methods:

After isolation of DNA by ethanol precipitation we determined ABCA1 gene polymorphism by using polimerase chain reaction - restriction fragment lenght polymorphism (PCR-RFLP) method in 107 type 2 diabetic patients and 50 healthy controls.

Results:

We have observed that the frequency of TT genotype is significantly higher in healthy controls compared to patients (14% vs. 3%; P = 0.008). Also frequency of T allele was higher in controls than in patients (34% vs. 21%; P = 0.020; OR (95% CI) = 0.52 (0.30–0.88)). There was no association of lipid levels and ABCA1 C69T polymorphism subgroups.

Conclusion:

We have found significantly higher frequency of both T allele and genotype in control group when compared to patients that made us think that T allele may be a protective factor against diabetes mellitus. But, we could not find a relationship between genotypes and lipid concentrations in our two groups. Larger studies will help us to understand the relationship between ABCA1 C69T genotype and lipid parameters in diabetes mellitus.  相似文献