| 运动训练对心理应激大鼠神经内分泌免疫若干指标的影响 |
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| 引用本文： | 尹剑春,颜军.运动训练对心理应激大鼠神经内分泌免疫若干指标的影响[J].北京体育大学学报,2006,29(1):70-73. |
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| 作者姓名： | 尹剑春 颜军 |
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| 作者单位： | 1. 江苏淮阴师范学院体育系,江苏,淮阴,223001
2. 扬州大学体育学院,江苏,扬州,225009 |
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| 基金项目： | 江苏省教育厅自然科学基金
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扬州大学校科研和教改项目 |
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| 摘 要： | 为了研究运动训练对神经内分泌免疫的影响及其可能机制.将54只SD雄性大鼠,随机分为安静对照组、心理应激组、应激 30min运动组、应激 60min运动组、30min运动组、60min运动组、电击组(除30min运动组和应激 30min运动组每组7只以外,其余每组8只).结果发现:1)与对照组相比,应激组大鼠血清IL-2水平显著低于对照组;CD3 、CD4 、CD8 水平无显著差异但有下降的趋势,血清皮质酮含量显著高于对照组.这表明反复的心理应激引起大鼠较强的HPA轴反应对大鼠免疫功能有抑制作用.2)与对照组相比,30min和60min运动组血清IL-2水平和血浆T细胞亚群数目都显著高于对照组,而血清皮质酮含量显著低于对照组.中小负荷运动有效地提高了大鼠机体免疫功能并使HPA轴产生适应性变化.3)与应激组相比,应激 60min运动组IL-2和CD3 ,CD4 /CD8 水平显著高于应激组;应激 30min运动组CD4 /CD8 水平无显著差异,但并不低于应激组,皮质酮含量显著低于应激组.说明运动训练可以通过改变HPA轴的应激激素的变化对抗心理应激造成的免疫功能的低下,且中等负荷对抗心理应激有着十分重要的意义.表明:反复的心理应激引起大鼠较强的心理反应并使大鼠免疫功能产生抑制,中小负荷运动对在心理应激下的大鼠免疫功能有较好的保护作用,且中等负荷运动更能提高大鼠抗应激能力,其可能机制在于中小负荷运动使得大鼠HPA轴产生较好的适应性,改变了应激激素在体内的分泌,从而维持了机体免疫功能的稳定.
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| 关 键 词： | 免疫 心理应激 运动 T淋巴细胞亚群 皮质酮 白细胞介素2 运动训练 心理反应 应激大鼠 神经 内分泌免疫 指标 影响 Stress Mental Rats System Training Exercise Effects 稳定 应激能力 抑制作用 的保护 意义 中等负荷 |
| 文章编号： | 1007-3612(2006)01-0070-04 |
| 修稿时间： | 2004年7月13日 |
Research on Effects of Exercise Training on Several Indexes of Neuroimmune System of Rats after Mental Stress |
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| YIN Jian-chun,Yan Jun.Research on Effects of Exercise Training on Several Indexes of Neuroimmune System of Rats after Mental Stress[J].Journal of Beijing Sport University,2006,29(1):70-73. |
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| Authors: | YIN Jian-chun Yan Jun |
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| Abstract: | Object: In order to explore effects of the exercise training on the Pschoneuroimmunology and its possible mechanism.Methods SD rats were divided into 7 groups randomly,which were the control group,psychological group,exercise group under stress for more than 30min,exercise group under stress for more than 60min,30min exercise group,60min exercise group,electrical footshock group.(every group has 8 pieces except for the 30min exercise group and the stress plus 30min exercise group).Results:(1) when compared with the control group,the IL-2 level of psychological stress was significantly lower than that of control group;the number of CD3 and CD4 /CD8 of psychological stress group had no significant change,but had the lower trend,while their corticosterone level was significantly higher than that of control group;these results indicated that repeated psychological stress produced significant reaction of the HPA system and depressed the immune system of rats;(2) when compared with the control group, the IL-2 and CD3 ,CD4 /CD8 levels of both 30min group and 60min group were significantly higher than that of control group,while their corticosterone level was dramatically lower than that of control,which indicated that the low and moderate exercise effectively improved the immune system of the rats and made the adaptive change of the HPA;(3) when compared with the stress group,the IL-2 and CD3 ,CD4 /CD8 levels of both 30min stress group and 60min stress group were significantly higher than that of stress group,while their corticosterone level was significantly lower than that of stress group.This demonstrated that the exercise training could change hormone of the HPA and attack the depression that was generated by the psychological stress.Conclusion: repeated psychological stress stimulated relatively strong psychological reaction of rats and depressed the immune function of rats;low and moderate exercise could effectively protect the immune system of rats which were under the psychological reaction and the moderate exercise can effectively improve the anti-stimulation ability of rats.The possible mechanism is that the exercise changed the adaptation of HPA and modified the excretion of the hormone,thereby maintaining the stability of the immune system. |
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| Keywords: | psychological stress exercise T lymphocyte subsets corticosterone IL-2 |
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