Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

‘This could be our reality in the next five to ten years’: a blogpost platform as an expectation generation device on the future of insurance markets     

Gert Meyers  Ine Van Hoyweghen 《Journal of Cultural Economy》2018,11(2):125-140

William James (1919) characterises hypotheses as either live or dead. A hypothesis is live when it is taken into account as a ‘real possibility’. We follow James’ suggestion to not attribute intrinsic properties to hypotheses, but rather investigate how they came into being and look at the effects they generate. Expectations of digital technologies are a topic of vivid debate in the insurance industry. Before these expectations can become ‘live’, they have, in the first place, to be generated by market devices. We investigate how the reinsurance blogpost platform Open Minds functions as an ‘expectation generation device’ on the future of insurance markets. Combining Beckert’s work on the role of fictional expectations with the pragmatist turn in sociology of markets, we propose to study ‘expectation generation devices’, provoking expectations on economic markets. In our empirical analysis, we demonstrate the explicit fictional character of the Open Minds contributions, and analyse how a contained space of openness is generated to provoke expectations. We demonstrate how Open Minds can become live through circulation to other expectation generation sites in the insurance industry and beyond. We conclude by reflecting on the importance of expectation generation devices as a particular type of market devices.  相似文献   

Discrete Choice Modeling in Education: An Innovative Method to Assess Teaching Practices     

Vasilis Grammatikopoulos  Athanasios Gregoriadis  Michalis Linardakis 《Educational Measurement》2019,38(3):46-54

Self‐reported measures are an easy, time‐efficient, and low‐cost way to collect research data compared to other assessment methods. They are, however, characterized by several limitations regarding the quality and the clarity of the data they produce, especially when they are implemented in education. The main purpose of the current study was to use a method called discrete choice modeling (DCM) in education, in order to develop a self‐reported instrument that will reduce the bias for socially desirable responses and to assess teachers’ practices in physical activity. DCM method has the ability to overcome the respondents’ tendency to answer in a socially desirable way. A nationally representative sample of 531 Greek early educators participated in this study and were administered a self‐assessment questionnaire based on DCM. Results showed that the DCM based newly developed instrument manages to assess effectively educators’ practices and provided evidence of the applicability of the method in education. Further implications and future recommendations regarding the effective application of DCM in education are discussed.  相似文献   

高职院校顶岗实习管理机制构建探析     

李耀辉  许春龙  赵成 《苏州市职业大学学报》2021,(1)

顶岗实习是实现高职人才培养目标的重要途径。鉴于当前高职顶岗实习中学校、学生及教师各层面都存在的问题,重新设计了顶岗实习的流程体系,通过校、企、师、生、家五方联动,构建了五途径保障实习岗位、两维度驱动实习成效、四层次规范实习管理、三主体强化实习评价的“五二四三”顶岗实习模式,实现学生、企业、教师、家长、导师和学校的六方共赢。  相似文献   

下一代图书馆系统平台的实践与思考     

邵波  张文竹 《图书情报工作》2019,63(1):98-104

[目的/意义]大数据与人工智能等技术为图书馆智慧服务带来机遇与挑战，图书馆新系统平台建设刻不容缓。旨在探讨下一代图书馆系统平台发展现状及对策，为建设一流高校智慧图书馆提供实践案例与参考依据。[方法/过程]梳理图书馆系统平台发展脉络，在盘点现有的国内外下一代图书馆系统平台的研究与实践的基础上，以南京大学为例，探索图书馆新系统平台的建设方案。[结果/结论]智慧图书馆将通过建设一体化电子资源管理平台并打造NLSP，提升图书馆资源管控和知识服务水平，构建开放共享的智慧图书馆服务体系。  相似文献   

‘Who is zooming who’? A study of young PE-students in their figurations     

Stine Frydendal Nielsen  Lone Friis Thing 《Sport, Education and Society》2019,24(5):480-490

The article presents an analysis of 93 essays written in an upper secondary school context. The essays were collected in relation to a larger research project, which went on for 5 years in a Danish upper secondary school (2010–2015). The material represents both genders and the students are 15–17 years old. We deploy a theoretical framework taken from Norbert Elias’ notion on established-outsider relations [Elias, N., &; Scotson, J. L. (1994 [1965]). The established and the outsiders. London: SAGE] as well as his use of personal pronouns [Elias, N. (1978). What is sociology? London: Hutchinson, Elias, N. (2001). The society of individuals. New York: The Continuum International Publishing Group] in illustrating how people negotiate, position and navigate within figurational contexts [Elias, N. (1994 [1939]). The civilizing proces. Oxford: Blackwell.]. We do this in an effort to interpret how young people negotiate ‘we-I-relations’ when it comes to their sporting identity. Elias’ processual framework provides a tool for a much needed analysis of how young people continually orientate and develop their sense of selves. The web of human interdependencies and processes of change are key words when it comes to understanding the social practices and doings of the students’ constructions of self-steering. What social scientists may see as laziness and drop-outs of sports [Seippel, Ø. (2016). Prek, vekker og kjedelig? Trening og mening blant ungdom: 1985–2013. In Ø. Seippel, M. K. Sisjord, &; Å Strandbu (Eds.), Ungdom og Idrett. Oslo: Cappelen Damm Akademisk] can in the essays of students be analysed as a struggle for group connectedness and social inclusion in the classroom. The results of our research show that identity is a multiple concept and an ongoing process of emotional work [Elias, N. (1987). On human beings and their emotions: A process-sociological essay. Theory Culture Society, 4, 339–361], but also a power balance of playing and presenting what is imagined as the right performance as not being shamed as outcasts.  相似文献   

欧洲阅读联盟(EURead)推广阅读活动与启示     

吴汉华  倪弘 《图书情报工作》2019,63(13):114-121

[目的/意义]欧洲阅读联盟是欧洲社会力量开展阅读活动的母平台，联盟成员所开展的阅读活动既有差异，也有共性，社会影响力大。通过对欧洲阅读联盟成员所办阅读活动及其规律的分析，可为我国公共图书馆主导与开展阅读活动提供借鉴。[方法/过程]概述欧洲阅读联盟，对其成员类型进行解析，并对每一成员的阅读项目进行共性分析，凝练出阅读活动的经验及规律。[结果/结论]我国应建立多级阅读推广力量，建立政府购买阅读服务长效机制，开放图书馆的阅读活动空间，提升阅读活动频率，开发多样化、差异化的阅读活动。  相似文献   

学习团队协作信息搜索的共享心智模型研究   总被引：1，自引：0，他引：1  

颜端武  张馨月  汤佳丽  苏琼 《图书情报工作》2020,64(8):3-12

[目的/意义] 对协作信息搜索进行深入研究，为专业化协作信息搜索系统平台建设优化等提供启发和借鉴。[方法/过程] 聚焦于学习团队的信息搜索行为，以高校学生为研究样本，以共享心智模型为切入点，采用扎根理论研究方法，探讨协作信息搜索中团队共享心智模型建构过程。[结果/结论] 识别出四大核心环节——个体感知与探索、团队任务解析、团队信息收集和团队信息整合，并理清各环节的认知活动与共享心智模型内容要素。  相似文献   

图书流通数据分析的H类指数遴选及应用——以西北农林科技大学图书馆为例     

净玲娣  王立宏  王芹  李雅 《图书情报工作》2020,64(9):65-72

[目的/意义] 优化藏书采访工作和流通管理，实现对藏书采访、藏书总量和结构等状况适时监测、评估、调控等的标准化管理。[方法/过程] 通过对H类指数中的H指数、A指数和G指数相关性、变异性和适应性分析，遴选适用于图书流通数据分析的A指数，并根据帕累托定律采用A指数对西北农林科技大学图书馆2014-2018年的前20%的图书流通数据分别进行统计分析。[结果/结论] 研究结果表明：平均A指数对中图法一级类目与读者性别、读者专业、读者年级以及图书出版社、图书出版年、单位等数据统计分析具有较理想的表现，能够更全面、准确地遴选核心读者群、核心出版者和核心出版年；同时发现，布拉德福定律不仅能够应用于期刊管理，而且能够应用于藏书管理。本文研究能够为探索H类指数分析高校图书馆藏书流通数据提供参考依据。  相似文献   

学术论文研究亮点的语言学特征与分布规律研究     

索传军  于果鑫 《图书情报工作》2020,64(9):104-113

[目的/意义] 论文出版过程中，若能够合理有效地呈现出一篇学术论文的核心观点，不仅可以大大减少科研人员在查找和筛选文献上花费的时间，而且有助于阅读与理解。[方法/过程] 通过标注385篇XML格式期刊论文，构建了研究语料库，再利用关键词分析法对亮点的语言学特征进行分析，借助自然语言处理算法探索亮点的分布特征。[结果/结论] 亮点是一组规范的、语义明确的短句的集合，是一篇学术论文与其他论文相比较的新观点、新视角、新方法、新思路、新结果、新结论等内容的体现。亮点具有新颖性、简明性、易读性、"宣传"性等特点。亮点分为研究创新型亮点、研究方法型亮点、研究过程型亮点与研究结论型亮点，本文发现了亮点在正文和各章节的分布情况。  相似文献