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41.
目的：研究乳腺癌中HDC4基因蛋白的表达及其临床病理学意义。方法：实验共选取91例乳腺组织的存档蜡块标本,其中包括46例乳腺癌、26例导管内原位癌（DCIS）以及19例正常宫颈上皮组织。应用免疫组织化学（SP法）检测HDC4蛋白在上述组织中的表达,并分析其蛋白检测的临床病理学意义。结果：与正常乳腺组织（15.8%,3/19）相比,HDC4蛋白在DCIS和乳腺癌组织中表达率明显增高,分别达46.2%(12/26)和71.7%(33/46),强阳性表达率在DCIS和乳腺癌组织中分别达19.2%（5/26）和45.6%（21/46）,也明显高于正常乳腺组织,差异显著（p<0.01）。结论：HDC4蛋白表达可作为女性乳腺癌及原位癌DCIS的病理辅助诊断指标之一,可能有助于乳腺癌的诊断及预后评估。 相似文献
42.
[目的]研究β-连环素与p63基因在大鼠舌部鳞状细胞癌中的表达,探讨它们在口腔鳞状细胞癌增殖中的作用.[方法]免疫组织化学方法检测48例不同分化程度大鼠舌部鳞状细胞癌中β-连环素与p63基因的表达.[结果]8例高分化口腔鳞状细胞癌中分别有7和6例高表达p63与β-连环素.β-连环素和p63表达与大鼠舌部鳞状细胞癌的组织学分级不具有显著性差异(P>0.05).[结论]β-连环素在大鼠舌鳞状细胞癌增殖中的作用与在人回顾性研究中的作用相似. 相似文献
43.
ＩＮＴＲＯＤＵＣＴＩＯＮＡｎｔｉｓｅｎｓｅｏｌｉｇｏｄｅｏｘｙｎｕｃｌｅｏｔｉｄｅｓ (ＡＳＯＤＮ )ｃａｎｉｎｈｉｂｉｔｔｒａｎｓｃｒｉｐｔｉｏｎａｎｄｉｎｔｅｒｆｅｒｅｗｉｔｈｓｐｅ ｃｉａｌｇｅｎｅｅｘｐｒｅｓｓｉｏｎ .ＡｆｉｘｅｄｐｏｉｎｔｏｎｔｈｅＫ ｒａｓｇｅｎｅｗｉｔｈｈｉｇｈｍｕｔａｔｉｏｎｒａｔｅｉｎｐａｎｃｒｅａｔｉｃｃａｒｃｉ ｎｏｍａｏｆｆｅｒｓａｎｉｎｔｒａｃｅｌｌｕｌａｒｔａｒｇｅｔｆｏｒｐａｎｃｒｅａｔｉｃｃａｒｃｉｎｏｍａｇｅｎｅｔｈｅｒａｐｙｗｉｔｈＡＳＯＤＮ (Ｃａｉ… 相似文献
44.
Chong Lai Ren-an Jin Xiao Liang Xiu-jun Cai 《Journal of Zhejiang University. Science. B》2016,17(3):236-246
Objective
Three mainstream techniques—laparoscopic hepatectomy (LH), percutaneous radiofrequency ablation (pRFA), and open hepatectomy (OH)—were compared in this study, in terms of their efficacies in the treatment of small hepatocellular carcinoma (HCC).Methods
A comparative study was performed within a total of 94 patients diagnosed with small HCC in our hospital from 2005 to 2010, who underwent LH (28), RFA (33), or OH (33). They had either a single tumor lesion of less than 5 cm or up to three nodules with diameters of less than 3 cm each. Outcomes were carefully evaluated throughout a 3-year follow-up interval and statistically interpreted.Results
The pRFA group had a significantly lower disease-free survival rate compared with the two surgical groups (P=0.001) and significantly shorter overall survival (P=0.005), while the LH group and the OH group had no difference in survival results. For patients younger than 60 years old, surgical approaches offered a better long-term overall survival prognosis (P=0.008). There were no statistically significant differences among the three groups in overall survival for elderly patients (P=0.104).Conclusions
Among patients with small HCC, LH may provide better curative effects than pRFA without increasing complication rates. pRFA leads to faster recurrence than surgical resections. LH has similar therapeutic effects to OH and causes less trauma. For patients younger than 60 years old, LH may be the best curative treatment. Elderly patients may choose either surgery or pRFA.45.
Objective: To study the effects of different concentrations of antisense oligodeoxynucleotides (ASODN) on human pancreatic
cancer cell line PaTu8988s. Method: Human pancreatic cancer cell line PaTu8988s in exponential growth stage was used to study
the effect of different drug concentrations on the cell line in the presence of different concentrations (0 μg/ml, 5 μg/ml,
25 μg/ml, 50 μg/ml, 10 μg/m, 200 μg/ml) of ASODN and sense oligodeoxynucleotides (SODN). Cell counts and 3-[4,5-dimethylthiazolzyl]-2,5-diphenyl
tetrazolium bromide (MTT) assays were carried out. Results: The inhibitory rate on the cell line PaTu8988s was 98.73%, 95.76%,
69.49%, 33.05% and 0 for ASODM concentrations of 200 μg/ml, 100 μg/ml, 50 μg/ml, 25 μg/ml and 5 μg/ml at 48 hours. Conclusions:
K-ras complementary ASODN can inhibit the growth of human pancreatic cancer cell line PaTu8988s by 30.05% to 98.73%. This
is likely to contribute to the specificity of the K-ras mRNA complementary capped ASODN sequential codon. Non-specific effect
and side effect of ASOND were observed for instance, the greater the concentration is, the earlier the peak of inhibitory
rate is reached. In concentration, of 25 μg/ml to 100 μg/ml ASODN showed a dose-effect correlation. 相似文献
46.
C. R. Wilma Delphine Silvia D. M. Vasudevan K. Sudhakar Prabhu 《Indian journal of clinical biochemistry : IJCB》2002,17(2):104-107
Serum β2-microglubin (β2-m) levels were measured in oral carcinoma patients and compared with normal healthy controls. It was observed that there
was a significant rise in serum β2-microglobulin in oral carcinoma patients. Progressively higher values were obtained as the cancer advanced clinically. Therefore
the estimation of serum β2-microglobulin may be useful as one of a battery of tests in the assessment of oral carcinoma patients. 相似文献
47.
48.
目的：探讨影响涎腺粘液表皮样癌患者术后生存的相关病理因素。方法：对98例涎腺粘液表皮样癌患者进行回顾性研究,分析影响患者术后生存的相关临床病理因素。通过SPSS10.0软件分析,筛选出影响粘液表皮样癌患者术后生存的主要临床病理因素。结果：与术后生存率相关的主要临床病理因素包括：临床分期、患者年龄、镜下是否发现坏死。结论：临床分期、患者年龄是影响涎腺粘液表皮样癌术后生存的主要临床因素,镜下坏死是影响涎腺粘液表皮样癌患者术后生存的主要病理因素。 相似文献
49.
殷俊才 《泰州职业技术学院学报》2005,5(3):39-40
目的探讨乳腺癌的早期诊断方法。方法40岁以上、直径2cm以下乳房纤维瘤行手术切除活检；触不到肿块的乳头血性溢液行导管切除活检；40岁以上乳房囊性增生病行区段切除活检；不明原因的腋下肿大的淋巴结切除活检。结果乳房纤维瘤6．8％为早期癌；乳头血性溢液58.3％(7／12)为乳头状瘤；乳房囊性增生病10.3％为早期癌；不明原因的腋下肿大的淋巴结60．0％(3／5)为早期癌。结论对40岁以上乳房纤维瘤行切除活检；对触不到肿块的乳头溢液行导管切除活检；对40岁以上乳房囊性增生病行区段切除活检；对不明原因的腋下肿大的淋巴结切除活检可早期诊断乳腺癌。 相似文献
50.
Inducible nitric oxide synthase expression is related to angiogenesis, bcl-2 and cell proliferation in hepatocellular carcinoma 总被引：3，自引：0，他引：3
ＩＮＴＲＯＤＵＣＴＩＯＮＮｉｔｒｉｃｏｘｉｄｅ (ＮＯ) ,ａｓｈｏｒｔｈａｌｆ ｌｉｆｅｒａｄｉｃａｌ,ｉｓｈｉｇｈｌｙｒｅａｃｔｉｖｅ ,ａｎｄｉｓｉｎｖｏｌｖｅｄｉｎｍａｎｙｂｉｏ ｌｏｇｉｃａｌｐｒｏｃｅｓｓｅｓ,Ｉｔｓｅｅｍｓｔｏｐｌａｙａｎｉｍｐｏｒｔａ 相似文献