Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

The Clarke County (Alabama) War Memorial: Kairos and Chronos United in the Sacred Commemoration and Contemplation of Five Wars     

Alison I. English 《Journal of American culture (Malden, Mass. : 2003)》2004,27(4):384-405

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教练员与运动员关系的研究   总被引：7，自引：0，他引：7  

程云峰  姜丽  杨太胜  王阜存  李金珠  张晓蓬 《山西师大体育学院学报》2002,17(2):51-53

我国竞技体育,教练员与运动员关系好的不乏其人,他们努力训练,通力合作,为我国的竞技体育的腾飞作出了卓越的贡献,但也有些教练员与运动员关系不融洽,使运动员过早地离开运动场,失去了为国争光的机会。文章通过教练员和运动员关系的研究,旨在为提高竞技运动水平和教练员在选材、训练时提供参考。  相似文献   

健康——不可忽视的人力资本投资     

傅玲  白文飞 《首都体育学院学报》2002,14(3):27-28

健康作为一种人力资本投资对提高生产力、促进经济发展和个人发展有着重要的作用。它可以提高劳动者的生产效率，刺激教育方面的投资，使人具有更多的时间和能力利用其他资本要素，具有更大的财力（因减少医疗费用）用于其他方面的投资。所以进行人力资本投资时，不可忽视健康这一要素，它也是人力资本形成的重要途径，也对经济增长起着有力的推动作用。  相似文献   

Investigation of Poor Academic Achievement in Children with Duchenne Muscular Dystrophy     

V. J. Hinton  D. C. De Vivo  R. Fee  E. Goldstein  Y. Stern 《Learning disabilities research & practice》2004,19(3):146-154

Duchenne Muscular Dystrophy (DMD) is a neurogenetic developmental disorder that presents with progressive muscular weakness. It is caused by a mutation in a gene that results in the absence of specific products that normally localize to muscle cells and the central nervous system (CNS). The majority of affected individuals have IQs within the normal range, generally with lower verbal than performance IQ scores. Prior work has demonstrated selective deficits on tests of verbal span and immediate memory. For the current study, 26 boys with DMD (and normal intellectual function) and their unaffected siblings were evaluated. Paired comparisons demonstrated that the children with DMD had significantly poorer academic achievement scores than their siblings, even though their vocabulary levels and home and educational environments were comparable. Children with DMD also had more behavioral concerns, physical disabilities, and poorer verbal memory spans. Linear regression indicated that behavioral concerns, executive function, and physical disability did not contribute substantially to academic performance, whereas performance on verbal span did. DMD presents with a selective developmental aberration in verbal span that has wide‐ranging consequences on learning skills.  相似文献   

我国体育用品业未来发展走向初探   总被引：16，自引：0，他引：16  

叶德初  王蓉 《武汉体育学院学报》2001,35(5):39-41

通过对我国体育用品市场需求量,以及体育用品业存在的问题和面临的挑战的分析,认为产业升级是我国体育用品业未来发展的主要走向.  相似文献   

全民健身与普通高校体育教育管理   总被引：8，自引：0，他引：8  

商勇  孙占光  娄德玉 《中国体育科技》2001,37(1):39-41

本研究运用A.E.SAATY教授提出的AHP层次分析法，对高校体育教育管理目标体系进行系统分析，明确了普通高校体育教育管理体系，建立了判断矩阵，并提出了该管理系统第3层目标的19个构成因素。  相似文献   

体育明星作形象代言人推行品牌产品的战略效应分析   总被引：2，自引：0，他引：2  

乐仁油  王丹虹  庄德  徐志雄 《哈尔滨体育学院学报》2005,23(6)

运动鞋企业是晋江经济的支柱,其发展对晋江经济和体育产业的发展有着重要的意义。值此第七届晋江(国际)鞋业博览会之际,运用文献资料、调查访问、观察及网上查询等研究方法,并运用经济学、广告学等相关学科的一些原理,分析了福建晋江运动鞋企业聘请体育明星作形象代言人推行品牌建设的现状及存在的一些主要问题,并提出了进一步推动晋江运动鞋企业品牌建设的一些对策和建议,以便给当地政府及相关的决策者提供一些理论参考。  相似文献   

每球得分制条件下影响一攻、防反关系的主要因素的研究——兼谈中国女排与世界女排的比较   总被引：3，自引：0，他引：3  

张桂青  张德广  钟霖 《中国体育科技》2002,38(5):27-31

通过对 1998年世界女子排球锦标赛、1999年世界杯女子排球赛与 1999年、2 0 0 0年全国女子排球甲级联赛的研究 ,对每球得分制条件下影响一攻和防反的主要因素进行论证。结果表明 :发球、一传效果、防守效果、不同风格打法和运动员心理素质是影响每球得分制条件下一攻、防反效果的主要因素 ;与世界强队相比 ,中国女子排球队在后排进攻方面存在着显著性差异  相似文献   

Cerebral activity prior to motion task performance: an electroencephalographic study     

D Collins  G Powell  I Davies 《Journal of sports sciences》1991,9(3):313-324

Cerebral activity, as reflected by power in the alpha waveband (8-13 Hz), was examined prior to the performance of three tasks with different effort and accuracy requirements. The study aimed to further investigate changes in activity observed in an earlier study in which expert karate performers exhibited significant increases in alpha band power during preparation for a training task. In contrast to the earlier research, the high effort task produced a significant decrease in 'alpha' power prior to performance. 'Alpha' power prior to the high accuracy task showed significant differences mediated by the outcome. Successful performance was preceded by higher levels of 'alpha' power than unsuccessful attempts. The reported use of a cognitive strategy on the first task produced a significant difference in activity, lower alpha power being associated with the use of such a technique.  相似文献