Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

学习团队协作信息搜索的共享心智模型研究   总被引：1，自引：0，他引：1  

颜端武  张馨月  汤佳丽  苏琼 《图书情报工作》2020,64(8):3-12

[目的/意义] 对协作信息搜索进行深入研究，为专业化协作信息搜索系统平台建设优化等提供启发和借鉴。[方法/过程] 聚焦于学习团队的信息搜索行为，以高校学生为研究样本，以共享心智模型为切入点，采用扎根理论研究方法，探讨协作信息搜索中团队共享心智模型建构过程。[结果/结论] 识别出四大核心环节——个体感知与探索、团队任务解析、团队信息收集和团队信息整合，并理清各环节的认知活动与共享心智模型内容要素。  相似文献   

Validity and reliability of a linear positional transducer across commonly practised resistance training exercises     

Harry F. Dorrell  Joseph M. Moore  Mark F. Smith  Thomas I. Gee 《Journal of sports sciences》2019,37(1):67-73

This study investigated the validity and reliability of the GymAware PowerTool (GPT). Thirteen resistance trained participants completed three visits, consisting of three repetitions of free-weight back squat, bench press, deadlift (80% one repetition maximum), and countermovement jump. Bar displacement, peak and mean velocity, peak and mean force, and jump height were calculated using the GPT, a three-dimensional motion capture system (Motion Analysis Corporation; 150 Hz), and a force plate (Kistler; 1500 Hz). Least products regression were used to compare agreeability between devices. A within-trial one-way ANOVA, typical error (TE; %), and smallest worthwhile change (SWC) were used to assess reliability. Regression analysis resulted in R² values of >0.85 for all variables excluding deadlift mean velocity (R² = 0.54–0.69). Significant differences were observed between visits 3-2 for bench press bar displacement (0.395 ± 0.055 m; 0.383 ± 0.053 m), and deadlift bar displacement (0.557 ± 0.034 m; 0.568 ± 0.034 m). No other significant differences were found. Low to moderate TE (0.6–8.8%) were found for all variables, with SWC ranging 1.7–7.4%. The data provides evidence that the GPT can be used to measure kinetic and kinematic outputs, however, care should be taken when monitoring deadlift performance.  相似文献   

充分发挥档案在高校工作中的作用     

钱苏娟 《扬州教育学院学报》2003,21(2):82-84

学校档案全宗是高校的宝贵财富,它为学校领导决策服务、为广大教职工从事学校管理、教学科研等工作提供可靠的依据和参考。因此,只有了解和掌握档案利用者的需求特点,规范档案管理,充分挖掘档案信息资源,提高档案工作者的素质,才能高效发挥档案在高校工作中的作用。  相似文献   

The Clarke County (Alabama) War Memorial: Kairos and Chronos United in the Sacred Commemoration and Contemplation of Five Wars     

Alison I. English 《Journal of American culture (Malden, Mass. : 2003)》2004,27(4):384-405

  相似文献   

程堅甫:中國當代農民中的古典詩人——一個被沉埋的詩人和一個被沉埋的詩道     

蘇煒 《中国文化》2008,(1)

"逢人说项斯" 此文的寫作,有一個故事套故事的緣起. 旅居舊金山的散文家劉荒田兄,傳來一篇他記寫廣東故鄉臺山一位已故老詩人程堅甫的詩詞創作和人生故事的文字.  相似文献   

跨国企业集团面临的汇率风险及其规避     

苏华 《济宁师范专科学校学报》2004,25(6):77-78,80

入世后，我国的市场适步向国际开放，我国企业也在不断走向国际市场。国际交易的频繁发生，不可避免地会对跨国企业集团产生一些影响。其中，汇率风险对任何跨国企业来说，都是一个不可避免的问题。那么，就目前而言，跨国企业面临的风险有哪些，如何去规避或降低这些风险，笔者就此作一些简单的分析，供大家参考。  相似文献   

大学生运动休闲文化探析   总被引：1，自引：0，他引：1  

苏斌  刘伟 《吉林体育学院学报》2004,20(3):33-34

从运动休闲概念的释义入手，以文献资料为基础，从社会学与文化学的角度，就大学生运动休闲文化的形成、内容、形式及其延伸等方面进行了阐释。  相似文献   

大学体育与社会群众体育的比较研究     

才化冰  苏长滨  吴子赋  闫桂兰  丁健 《哈尔滨体育学院学报》2004,22(2)

为比较大学体育与社会群众体育的异同 ,对黑龙江省内外 9所大学的部分学生和省内主要城市厂矿、企事业单位、社区、街道等部分社会群众成员进行问卷调查、专访。并查阅有关图文资料 ,对大学体育与社会群众体育进行了比较研究。结果显示 :在大学体育和群众体育这两个领域内 ,由于在时间、空间、地域和人文环境上 ,学习、工作和生活条件的不同 ,以及所受教育的程度不同 ,对体育运动的参与能力、参加活动的时间、场所及组织形式上、对健身目的认识和体育消费结构上都存在明显的差异性。为进一步开展社会群众体育 ,建议政府主管部门加强对社会群众组织的投入 ,利用大学优势培养社会体育指导员 ;加强体育设施建设 ;大力宣传健康与体育的关系和体育的功能。  相似文献   

教练员与运动员关系的研究   总被引：7，自引：0，他引：7  

程云峰  姜丽  杨太胜  王阜存  李金珠  张晓蓬 《山西师大体育学院学报》2002,17(2):51-53

我国竞技体育,教练员与运动员关系好的不乏其人,他们努力训练,通力合作,为我国的竞技体育的腾飞作出了卓越的贡献,但也有些教练员与运动员关系不融洽,使运动员过早地离开运动场,失去了为国争光的机会。文章通过教练员和运动员关系的研究,旨在为提高竞技运动水平和教练员在选材、训练时提供参考。  相似文献