Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

The Clarke County (Alabama) War Memorial: Kairos and Chronos United in the Sacred Commemoration and Contemplation of Five Wars     

Alison I. English 《Journal of American culture (Malden, Mass. : 2003)》2004,27(4):384-405

  相似文献   

Electronic circuits and tubes: by the Electronics Training Staff at the Cruft Laboratory,Harvard University. 948 pages,illustrations, 15 × 23 cm. New York,McGraw-Hill Book Co., Inc., 1947. Price, $7.50     

H.N. Michael 《Journal of The Franklin Institute》1948,245(6):533-534

  相似文献   

Detoxication mechanisms.The metabolism of drugs and allied organic compounds: by R. Tecwyn Williams. 288 pages, 14 × 22 cm. New York,John Wiley & Sons,Inc., 1948. Price, $5.50     

Henry N. Michael 《Journal of The Franklin Institute》1948,245(6):528

  相似文献   

Field practice: by Elwyn E. Seelye. A Data Book For Civil Engineers.306 pages,tables, drawings and illustrations, 13 × 211 curs. New York,John Wiley & Sons,Inc., 1947. Price $4.50     

H.N. Michael 《Journal of The Franklin Institute》1948,245(5):445-446

  相似文献   

Zur Geschichte Olympias in der Antike     

Michael Krüger 《Sportwissenschaft》2004,34(2):218-222

  相似文献   

儿童青少年运动员的营养需要     

Oded Bar-Or　Linda Houtkooper　Susan Barr　Anita Rivera-Brown　Michael Bergeron　Tom Rowland　Ruth Carey　Suzanne Steen　Priscilla Clarkson 《体育科学》2001,21(5):89-93

1. 儿童青少年运动员应该食用多样化的食物，其中，蛋白质应占膳食总能量的12％-15％，碳水化合物至少占55％，而脂肪至多占30％。日常生活中如何吃才能满足这些要求呢？膳食指南宝塔提供了一条可行之道。2.有些营养素对热爱运动的儿童青少年运动员非常重要，要保证摄入充足，这些营养素是碳水化合物（包括纤维素）、维生素B6、维生素D、铁、钙、镁、锌、铬。科学合理、包罗各类食物的平衡膳食，对青少年运动员最大程度地全面摄取各种营养素，满足生长发育和运动训练的需要，是非常必要的。3.鼓励儿童青少年运动员在运动训练前、中、后进行补液，以避免脱水的发生。4.如果膳食合理平衡，就没必要额外补充营养品。  相似文献   

Eine generische Komponente zur rechnergestützten Nutzung von Aufbauorganisationen     

Stefan Jablonski  Michael Schlundt und Hartmut Wedekind 《Informatik - Forschung und Entwicklung》2001,16(1):23-34

Zusammenfassung.   Die klassische Unterscheidung zwischen Aufbau- und Ablauforganisation eines Unternehmens deutet auf eine getrennte rechnergestützte Realisierung dieser beiden fundamentalen Komponenten einer Organisation hin. Dieser Beitrag unterstützt diese These, verweist aber gleichzeitig auf die integrierende Bedeutung einer rechnergestützten Aufbauorganisationsverwaltung, welche unterschiedliche Realisierungsformen der Ablauforganisation (unter anderem workflow-management und eCommerce) bedient. Die generelle Konzeption und Umsetzung einer solchen Aufbauorganisationsverwaltung wird in diesem Beitrag vorgestellt. Eingegangen am 14. Februar 2000 / Angenommen am 31. Mai 2000  相似文献   

教练员与运动员关系的研究   总被引：7，自引：0，他引：7  

程云峰  姜丽  杨太胜  王阜存  李金珠  张晓蓬 《山西师大体育学院学报》2002,17(2):51-53

我国竞技体育,教练员与运动员关系好的不乏其人,他们努力训练,通力合作,为我国的竞技体育的腾飞作出了卓越的贡献,但也有些教练员与运动员关系不融洽,使运动员过早地离开运动场,失去了为国争光的机会。文章通过教练员和运动员关系的研究,旨在为提高竞技运动水平和教练员在选材、训练时提供参考。  相似文献   

健康——不可忽视的人力资本投资     

傅玲  白文飞 《首都体育学院学报》2002,14(3):27-28

健康作为一种人力资本投资对提高生产力、促进经济发展和个人发展有着重要的作用。它可以提高劳动者的生产效率，刺激教育方面的投资，使人具有更多的时间和能力利用其他资本要素，具有更大的财力（因减少医疗费用）用于其他方面的投资。所以进行人力资本投资时，不可忽视健康这一要素，它也是人力资本形成的重要途径，也对经济增长起着有力的推动作用。  相似文献