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Kadam DP Suryakar AN Ankush RD Kadam CY Deshpande KH 《Indian journal of clinical biochemistry : IJCB》2010,25(4):388-392
Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various
exogenous and endogenous factors. It is associated with a number of biochemical and immunological disturbances. Recently,
it has been suggested that increased reactive oxygen species (ROS) production and compromised function of antioxidant system
may be involved in the pathogenesis of this disease. In the present study, 90 psoriasis patients were selected. Disease severity
was assessed by psoriasis area severity index score and grouped as mild, moderate and severe (each group consists of 30 subjects)
and compared with 30 healthy controls. Serum levels of malondialdehyde, nitric oxide end products and the activities of antioxidant
enzymes such as erythrocyte-superoxide dismutase, catalase and total antioxidant status were investigated in these groups/subjects.
As compared to controls, we found severitywise significantly increased serum malondialdehyde, nitric oxide end products with
decrease in erythrocyte-superoxide dismutase activity, catalase activity and total antioxidant status in patients with psoriasis
suggesting worsening of the disease. It seems to be linked with the enhancement of Reactive Oxygen Species production and
decreased antioxidant potential in psoriasis. 相似文献
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Seema Gupta Rajesh Pandey Ranjan Katyal H. K. Aggarwal R. P. Aggarwal S. K. Aggarwal 《Indian journal of clinical biochemistry : IJCB》2005,20(1):67-71
The present study was conducted to evaluate some of the components of antioxidant defense system and oxidative damage in 20
male patients of alcoholic liver disease (ALD). The results were compared with 20 healthy male smokers and 20 healthy male
non-smokers volunteers. Patients were subjected to detailed clinical examination and laboratory investigations. Blood samples
were collected for estimating reduced glutathione (GSH), total thiols (T-SH) malondialdehyde (MDA), transaminases (AST, ALT),
glutathione-S-transferease (GST) and gammaglutamyl transferase (GGT). Serum aspartate amino transferase (AST)/alanine amino
transferase (ALT) ratio was significantly (p<0.01) reduced in ALD patients as compared to the controls. However, the core
of utility of MDA and GST was found to be significantly (p<0.01) increased in ALD patients compared to controls. There was
a significant negative correlation of MDA with both GSH and TSH. Plasma GGT levels were significantly (p<0.01) increased in
alcoholics and the enzyme showed a significant positive correlation with MDA. These results give enough evidence of increased
oxidative stress and compromised antioxidant defense system in patients with ALD. 相似文献
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Bhawana Nigam S. P. Joshi Seema Nagar Rajesh Chavan D. Pendharkar 《Indian journal of clinical biochemistry : IJCB》1996,11(2):124-128
The analysis of biochemical parameters in 162 patients with various neoplastic disorders along with 50 normal subjects showed significant rise in serum alkaline phosphatase and lactate dehydrogenase as compared to normal subjects. 21 patients with other monoclonal gammopathies which include infection and immunological diseases were also studied. Parameters such as serum calcium, uric acid, total protein, albumin and globulin were also analyzed in 42 (26%) cases of multiple myeloma, 27 (17%) cases of gastro-intestinal malignancies, 22 (14%) cases of urogenital malignancies, 11 (6%) cases of carcinoma breast, 4 (2%) cases of bone tumors, 21 (12%) cases of other monoclonal gammopathies, including 7 (4%) cases of infection and 14 (8%) cases of immunological diseases. The results indicate use of enzymes alkaline phosphatase and lactate dehydrogenase in neoplastic disorders. 相似文献
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Rajesh KenoiJack 《海外英语》2008,(2):46-47
Jack现在南京任教,对这片土地的热爱促使他千里迢迢从印度来到中国。他很乐意与读者朋友们交流,他的E-mail地址是:jackkanoi@hotmail.com 相似文献
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Rajesh Kanoi 《海外英语》2007,(12):1
The air is a sea of gases, And the wind is restless waves;When it wants it can sustain life,And take it when it craves. A flame can live with ardor,Its posture straight and strong,When the wind is quiet and gentle,For it becomes a loving mate. And, then, when fancy strikes.It can blow a strong willed gust.That will extinguish a struggling flame,And turn to less than dust. The wind is air at peace,In love, it is a breeze;Disturbed and angry it becomes a storm,That tears down mighty trees. 相似文献
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Rajesh Kumar Kori Manish Kumar Singh Abhishek Kumar Jain Rajesh Singh Yadav 《Indian journal of clinical biochemistry : IJCB》2018,33(4):372-381
The problem of pesticides is not new and its exposure to human due to indiscriminate use is largely associated with the health related problems including neurotoxicological alterations. High levels of pesticide residues and their metabolites in the dietary constituents, food materials, maternal blood, cord blood, placenta breast milk have been reported and linked to alterations in birth weight, crown heel length, head circumference, mid-arm circumference and ponderal index of the neonates. Epidemiological studies have suggested that exposure of pesticide to human could be a significant risk factor for neurological disorders, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. Cholinergic and non-cholinergic dysfunctions in pesticide exposed population, especially in children have also been frequently reported in recent years. Developmental neurotoxicity is another concern in the area where pregnant are more prone towards its exposure and which results in the abnormalities in the fetus. In view of the increasing risk of human health through pesticide exposure, the present review has been focused on the studies pertaining to pesticide induced neurochemical alterations and associated behavioral abnormalities in farm workers which could establish a possible link between the its exposure and associated health hazards. 相似文献
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Rajesh Kanoi 《海外英语》2006,(11):36-37
I force myself to leave my computer and walk down for lunch. I have been writing all morning after my little jaunt down at the artificial-turfed playground for my run and exercise. It’s been a late start and breakfast,a simple meal consisting of whole-wh… 相似文献
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Rajesh Kanoi 《海外英语》2003,(2):22-23
The poems below are mostly from a novel that Jackwrites.Out of the context of the book,the poemsmay not quite carry the same impact as theywould,when reading with the text of the book.However,it will give you an idea of the content,itsphilosophical and metaphysical bent.Though,some-what like a stream of consciousness it is differentlydone. 相似文献
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Vasavidevi V. Bet Kishor H. Deshpande Adinath N. Suryakar Rajesh D. Ankush Raghavendra V. Katkam 《Indian journal of clinical biochemistry : IJCB》2006,21(2):177-180
Crystal aggregation and retention are critical events for the formation of kidney stones. There is a close association between
crystal development and free radical activity in vivo. In the present study 30 subjects presenting with urolithiasis were
included. Serum levels of total lipid peroxides, nitric oxide (as nitrite), α-tocopherol, plasma ascorbic acid (vitamin C)
and erythrocyte superoxide dismutase activity were measured. These findings were compared with 30 age matched control subjects
irrespective of sex. Student's ‘t’ test was applied for statistical analysis. There was a significant increase in lipid peroxides
(p<0.001), where as significant decrease in nitrite (p<0.01) and α-tocopherol (p<0.001) levels were observed. Plasma ascorbate
(p>0.05) and erythrocyte superoxide dismutase activity (p>0.05) was also found to be decreased but the difference was not
statistically significant which suggests that oxidative stress is evident in urolithiasis with depletion in antioxidant status
where as decrease in nitric oxide may be less abetting in disease condition. 相似文献