Impact of age on host responses to diet-induced obesity:Development of joint damage and metabolic set points     

Kelsey H.Collins  Graham Z.MacDonald  David A.Hart  Ruth A.Seerattan  Jaqueline L.Rios  Raylene A.Reimer  Walter Herzog 《运动与健康科学(英文)》2020,9(2):132-139,197

Background:Osteoarthritis is one of the leading causes of pain and disability worldwide,and a large percentage of patients with osteoarthritis are individuals who are also obese.In recent years,a series of animal models have demonstrated that obesity-inducing diets can result in synovial joint damage(both with and without the superimposition of trauma),which may be related to changes in percentage of body fat and a series of low-level systemic inflammatory mediators.Of note,there is a disparity between whether the dietary challenges commence at weaning,representing a weanling onset,or at skeletal maturity,representing an adult onset of obesity.We wished to evaluate the effect ofthe dietary exposure time and the age at which animals are exposed to a high-fat and high-sucrose(HFS) diet to determine whether these factors may result in disparate outcomes,as there is evidence suggesting that these factors result in differential metabolic disturbances.Based on dietary exposure time,we hypothesized that rats fed an HFS diet for 14 weeks from weaning(HFS Weanling) would demonstrate an increase in knee joint damage scores,whereas rats exposed to the HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult) and rats exposed to a standard chow diet(Chow)would not display an increase in knee joint damage scores.Methods:Male Sprague-Dawley rats were fed either an HFS diet for 14 weeks from weaning(HFS Weanling) or an HFS diet for 4 weeks,starting at 12 weeks of age(HFS Adult).At sacrifice,joints were scored using the modified Mankin Criteria,and serum was analyzed for a defined subset of inflammatory markers(Interleukin-6,leptin,monocyte chemoattractant protein-1,and tumor necrosis factorα).Results:When the HFS Weanling and HFS Adult groups were compared,both groups had a similar percent of body fat,although the HFS Weanling group had a significantly greater body mass than the HFS Adult group.The HFS Weanling and HFS Adult animals had a significant increase in body mass and percentage of body fat when compared to the Chow group.Although knee joint damage scores were low in all 3 groups,we found,contrary to our hypothesis,that the HFS Adult group had statistically significant greater knee joint damage scores than the Chow and HFS Weanling groups.Furthermore,we observed that the HFS Weanling group did not have significant differences in knee joint damage scores relative to the Chow group.Conclusion:These findings indicate that the HFS Weanling animals were better able to cope with the dietary challenge of an HFS diet than the HFS Adult group.Interestingly,when assessing various serum proinflammatory markers,no significant differences were detected between the HTS Adult and HFS Weanling groups.Although details regarding the mechanisms underlying an increase in knee joint damage scores in the HFS Adult group remain to be elucidated,these findings indicate that dietary exposure time maybe less important than the age at which an HFS diet is introduced.Moreover,increases in serum proinflammatory mediators do not appear to be directly linked to knee joint damage scores in the HFS Weanling group animals but may be partially responsible for the observed knee joint damage in the adults over the very short time of exposure to the HFS diet.  相似文献   

“生生之谓易”——试论《周易》的养生哲学     

姜守诚 《湖南科技学院学报》2008,29(6):9-14

<周易>包含了丰富的养生思想和生命智慧,是研究我国古代尤其是先秦时期的哲学、史学、民俗学以及养生学等的重要文献之一.文章从养生学角度着眼,探讨<周易>养生哲学的三个重要理论基础,并且从日常生活饮食等相关内容入手,具体分析<周易>养生学的几大特点及其包含的深层文化内涵.  相似文献   

控制肥胖运动处方研究   总被引：1，自引：0，他引：1  

吴继民 《泉州师范学院学报》2005,23(6):107-110

肥胖是现代社会的文明病之一，它不仅影响人们的形体美，而且严重危害人体的健康，文章从肥胖的病因和判断的指标入手，详细阐述运动减肥的机理、如何制定运动处方以及注意事项，为大家树立一个健康减肥的理念．  相似文献   

中国食育发展进程及机制构建研究     

周勤怡  石自彬  韩雨辰 《南宁职业技术学院学报》2021,(1):10-14

“食育”一词虽然源于日本,但中国古代一直都有食育,且食育思想和其他文化一起,都是中华文明的优秀文化组成。现代食育需要有外在的表现形式,并系统地将其发展、延伸表达出来以适应于食育的普及和推广。因此,现代食育制度的建设要从中华民族发展的实际需要和获取长期效益的角度出发,依据实际情况、历史遗存、教育模式、饮食风俗习惯等构建适合于自身发展的具有中国特色的食育制度体系。  相似文献   

浅析农村幼儿园平衡膳食实施的有效策略     

柴玉花 《天津教育》2021,(11):166-167,170

幼儿园作为幼儿膳食的主要提供者,主要负责研究营养搭配是否合理、营养素是否全面均衡、膳食质量是否优质等问题。面对越来越多的营养失衡幼儿,实施营养配餐刻不容缓,而只有平衡膳食才是把《中国居民膳食指南》真正落实到幼儿餐盘内的唯一途径,这对缺乏专业人士指导科学配餐的农村幼儿园尤为重要。  相似文献   

饮食譬喻：文学观念表达的特色之媒——中国古代文学艺术饮食化批评研究     

陈军 《江西师范大学学报(哲学社会科学版)》2006,39(5):62-65,71

中国古代文学艺术理论和批评中出现的众多饮食譬喻,蕴含着一系列值得关注的文学观念。这些文学观念的表达在譬喻的语境中更显自然、贴切、鲜活和生动,显示出譬喻性直觉思维的某些科学性层面,体现了中国古代文学艺术批评理论别样的存在方式。  相似文献   

英语习语与风俗习惯     

张江霞 《漯河职业技术学院学报》2007,6(1):179-180

语言作为文化的载体,它浸透了各个民族的不同文化,也会受到文化的影响.习语作为语言词汇的重要组成部分,必然会反映出所对应民族文化的一个主要组成部分--风俗习惯.本文从三个方面论述了风俗习惯对英语习语的影响.  相似文献   

日本幼儿食育活动的价值与思考     

张月  姜露  吕小耘  秦雯雯 《宁波教育学院学报》2020,(1):110-113,126

食育,是通过各种教育方式使国民学习与掌握饮食有关的知识,培养正确的饮食选择能力以及形成良好饮食习惯的一种教育。开展食育活动,要求将健康饮食的观念融入日常生活中,使幼儿从小养成良好的饮食态度和饮食习惯。文章以日本为例,通过探讨食育活动中所蕴含的对于幼儿身心发展以及教学工作开展的独特价值,对我国进一步推行食育计划提出有效建议。  相似文献   

“生生之谓易”—试论《周易》的养生哲学     

姜守诚 《零陵师范高等专科学校学报》2008,(6):9-14

《周易》包含了丰富的养生思想和生命智慧,是研究我国古代尤其是先秦时期的哲学,史学、民俗学以及养生学等的重要文献之一。文章从养生学角度着眼,探讨《周易》养生哲学的三个重要理论基础,并且从日常生活饮食等相关内容入手,具体分析《周易》养生学的几大特点及其包含的深层文化内涵。  相似文献   

从《说文解字》看古代与饮食有关的器具文化   总被引：1，自引：0，他引：1  

高燕 《怀化学院学报》2008,27(2):73-75

成书于东汉年间的《说文解字》(下简称《说文》),是我国第一部以六书理论系统分析字形,解释字义的字书。其中记载了与饮食有关的很多器具,从中不但可以了解古代与饮食有关的器具文化,而且还可以管窥古代的饮食文化。  相似文献