| 运动疲劳对大鼠海马和纹状体BDNF、GFAP蛋白表达的诱导作用 |
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| 引用本文： | 乔德才,侯莉娟.运动疲劳对大鼠海马和纹状体BDNF、GFAP蛋白表达的诱导作用[J].北京体育大学学报,2007,30(6):781-783. |
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| 作者姓名： | 乔德才 侯莉娟 |
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| 作者单位： | 北京师范大学体育与运动学院,北京,100875 |
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| 基金项目： | 国家自然科学基金
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山西省自然科学基金 |
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| 摘 要： | 目的观察运动疲劳对大鼠海马和纹状体脑源性神经营养因子(BDNF)及胶质纤维酸性蛋白(GFAP)表达的影响,探讨运动疲劳产生的神经生物学机制.方法:选取24只SD大鼠随机分为对照组(CG)和实验组(EG),分别在运动后0,12,24 h将大鼠麻醉,灌注制备脑石蜡切片,采用免疫组化染色法观察并分析海马和纹状体BDNF、GFAP表达水平的变化.结果EG海马锥体细胞排列紊乱疏松,部分细胞出现固缩、肿胀和碎裂;GFAP阳性细胞胞体增大,突起分支增多、增粗,着色加深.海马和纹状体12EG、24EG组BDNF阳性表达显著高于CG(P＜0.05,P＜0.01),且海马24EG显著高于0EG(P＜0.05).各EG大鼠海马区神经细胞GFAP阳性表达较CG明显增强(P＜0.05,P＜0.01).结论运动疲劳引起大鼠海马和纹状体BDNF和GFAP表达水平上调,提示BDND与CFAP参与了运动疲劳产生的神经生物学调控过程.
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| 关 键 词： | 运动疲劳 海马 纹状体 脑源性神经生长因子 胶质纤维酸性蛋白 运动疲劳 大鼠海马 纹状体 BDNF GFAP 蛋白表达 诱导作用 Rats Expression Fatigue Effects Striatum 过程 调控 神经生物学 增强 神经细胞 海马区 阳性表达 加深 |
| 文章编号： | 1007-3612(2007)06-0781-03 |
| 修稿时间： | 2005年6月20日 |
Effects of Exercise-induced Fatigue on the Expression of BDNF and GFAP of Rats' Hippocampus and Striatum |
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| QIAO De-cai,HOU Li-juan.Effects of Exercise-induced Fatigue on the Expression of BDNF and GFAP of Rats'''' Hippocampus and Striatum[J].Journal of Beijing Sport University,2007,30(6):781-783. |
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| Authors: | QIAO De-cai HOU Li-juan |
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| Abstract: | To investigate BDNF and GFAP expression changes in rats' hippocampus and striatum after swimming and discuss the neurobiology mechanism of exercise-induced fatigue,24 rats were divided randomly into CG and EG(0EG,12EG,24EG) and BDNF and GFAP expression changes in hippocampus and striatum were observed using SABC method.After exercise-induced fatigue,cells arrange shows foul-up and loosen in cone district of hippocampus.Some cells crinkle,strut and chip.GFAP expression in cell's body becomes augment and shows wider axon.Expression of BDNF in 12EG,24EG significantly increased compared with CG(P <0.05,P <0.01),and 24EG also significantly increased compared with 0EG(P <0.05).Expression of GFAP significantly increased compared with CG(P <0.05,P <0.01).Exercise-induced fatigues have increased BDNF and GFAP expression.It has been proved that both of BDNF and GFAP may play an important role in the neurobiological modulation for exercise-induced fatigue. |
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| Keywords: | exercise-induced fatigue hippocampus striatum BDNF GFAP |
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