Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

高职院校顶岗实习管理机制构建探析     

李耀辉  许春龙  赵成 《苏州市职业大学学报》2021,(1)

顶岗实习是实现高职人才培养目标的重要途径。鉴于当前高职顶岗实习中学校、学生及教师各层面都存在的问题,重新设计了顶岗实习的流程体系,通过校、企、师、生、家五方联动,构建了五途径保障实习岗位、两维度驱动实习成效、四层次规范实习管理、三主体强化实习评价的“五二四三”顶岗实习模式,实现学生、企业、教师、家长、导师和学校的六方共赢。  相似文献   

下一代图书馆系统平台的实践与思考     

邵波  张文竹 《图书情报工作》2019,63(1):98-104

[目的/意义]大数据与人工智能等技术为图书馆智慧服务带来机遇与挑战，图书馆新系统平台建设刻不容缓。旨在探讨下一代图书馆系统平台发展现状及对策，为建设一流高校智慧图书馆提供实践案例与参考依据。[方法/过程]梳理图书馆系统平台发展脉络，在盘点现有的国内外下一代图书馆系统平台的研究与实践的基础上，以南京大学为例，探索图书馆新系统平台的建设方案。[结果/结论]智慧图书馆将通过建设一体化电子资源管理平台并打造NLSP，提升图书馆资源管控和知识服务水平，构建开放共享的智慧图书馆服务体系。  相似文献   

学习团队协作信息搜索的共享心智模型研究   总被引：1，自引：0，他引：1  

颜端武  张馨月  汤佳丽  苏琼 《图书情报工作》2020,64(8):3-12

[目的/意义] 对协作信息搜索进行深入研究，为专业化协作信息搜索系统平台建设优化等提供启发和借鉴。[方法/过程] 聚焦于学习团队的信息搜索行为，以高校学生为研究样本，以共享心智模型为切入点，采用扎根理论研究方法，探讨协作信息搜索中团队共享心智模型建构过程。[结果/结论] 识别出四大核心环节——个体感知与探索、团队任务解析、团队信息收集和团队信息整合，并理清各环节的认知活动与共享心智模型内容要素。  相似文献   

图书馆科普教育现状与发展路径探究——基于25个省市88家科普教育基地调查     

徐基田 《图书情报工作》2020,64(9):35-45

[目的/意义] 图书馆肩负着实施科普教育的法定职责，拥有品种多样、内容丰富的科普文献与信息资源的图书馆，在开展科普教育方面具有得天独厚的优势。图书馆科普教育起步比较早，2005年，中国图书馆学会成立科普与阅读指导委员会；但在图书馆业界，科普教育只是零星的点缀式服务创新探索，尚未成为常态化服务项目。在依法治馆、创新发展的新时代，寻求图书馆科普教育发展路径具有较强理论和实践意义。[方法/过程] 通过互联网、微信等社交网络平台，对图书馆科普教育基地建设的状况进行调研，从基地等级、基地类型、基地数量、区域分布、有效期限以及认定依据等方面进行深入分析，并对图书馆实施科普教育提出发展路径以供选择。[结果/结论] 图书馆科普教育应坚持基地建设与科普服务相结合、阅读推广与全民科普相融合、科普与游学并举等策略，走设施、资源、服务"三位一体"的持续稳健协调发展之路。  相似文献   

图书情报学领域学科交叉及其国家差异的动态分析     

王思茗  滕广青 《图书情报知识》2020,(3):109-118,F0003

[目的/意义]领域知识的跨学科交叉研究能够打破学科间的壁垒,有助于发现重大科学问题的解决方案。[研究设计/方法]基于图书情报学领域文献题录信息构建轻量级领域知识图谱,从中提取学科信息、国家信息、时间信息及其关联,采用时间与空间相结合的多维度分析方法,对学科交叉的演化进程以及国家差异进行跟踪与分析。[结论/发现]图书情报学领域内学科交叉现象日渐显著,各国家的学科交叉程度与倾向存在差异,一些目前尚不突出的交叉学科方向值得关注。[创新/价值]采用多维度视角分析学科交叉现象,相关结论可以为国家科技战略制定及学科发展规划提供有益参考。  相似文献   

Data Visualization as Participatory Research: A Model for Digital Collections to Inspire User-Driven Research     

A. Miller 《Journal of Web Librarianship》2019,13(2):127-155

The emerging creative practices of digital collections are increasing in prominence thanks to the access to, and appeal of, data visualizations. Interactive data visualizations, such as a map, timeline, chart, graph, or artist’s rendering of data, enable users to pursue their own research interests within a collection and participate in new areas of research. Use of these data visualizations enhances the scope of the collection and enables a modern and diverse thematic collection to emerge. This article considers the question: Does the addition of data visualizations affect how users participate with a research collection? Impacts on collection development, application of user-centered design, and analysis of users’ exploratory strategies are discussed. Examples of data visualizations used in digital humanities projects and digital collections are presented as case studies.  相似文献   

高校田径教学存在的问题及对策研究     

陶月  王磊 《体育科技文献通报》2020,(2):59-60,99

在高校教育中,田径课程是一门价值深远的体育课程,它不仅有增强人体机能、改善体内系统的效能,同时还有拓展视野、扩大交际范围和增强自我能力的作用,作为在高校体育中占有重要位置的一门课程。在社会经济不断深入发展的历史新时期里,传统的田径教学同大学生的自我能力发展要求已经不相适应,本文在此基础上,总结了几点主要问题和几项解决措施,希望能够为相关高校的田径教学工作者提供参考。  相似文献   

Performative technologies and teacher subjectivities: A conceptual framework     

Hans Englund  Jonas Gerdin 《British Educational Research Journal》2019,45(3):502-517

Critical educational literature suggests that an increased reliance upon performative technologies is currently transforming the very foundations from which teacher subjectivities are constructed. Arguably though, the number of studies pointing to this risk or tendency is considerably larger than the ones theorising why this should be the case. Further, in those cases where the relationship between performative technologies and teacher subjectivities is theorised, the psychological mechanisms that the technologies appeal to are seldom brought to the fore. Based on this, the purpose of this article is to theorise the psychological mechanisms that performative technologies appeal to and work through, by means of identifying, systematising and elaborating extant understandings of such mechanisms in the critical educational literature. The results are presented in the form of a conceptual framework (referred to as the CMIS-framework) which suggests that one and the same performative technology may play many different roles, where each such role appeals to and works through a particular psychological mechanism. Importantly, depending on the type of psychological mechanism that is appealed to, the CMIS-framework suggests that this will lead to teachers (un)consciously conducting particular forms of subjectivising work upon themselves, here referred to as compliance, mirroring, identification and self-realisation (CMIS).  相似文献   

从传统走向现代：瑜伽精神实践的认知转向与模式转型     

刘丽云 《体育学刊》2020,(1):25-29

探讨了瑜伽现代化过程中精神实践的认知转向与推广模式转型及其影响。瑜伽在传统文化环境中是印度本土宗教中实现宗教目的的修行方式,是传统哲学中达到自我完满状态的重要途径,是通过离群苦修达到“梵我合一”的手段。在现代化过程中,瑜伽通过融合心灵哲学、引入世俗目标、融入现实生活等方式实现了精神实践的认知转向。在现代瑜伽推广过程中,通过增强主体的多元性、形式的时代性、内容的功能性等方式实现了推广模式的转型,为世界“瑜伽热”提供助力,也为中国传统体育运动的发展传播提供了启示。  相似文献